用于即时检测中细胞和微生物可视化的微型无透镜成像系统。
Miniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testing.
机构信息
Demirci Bio-Acoustic MEMS in Medicine (BAMM) Labs at the HST-BWH Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Biotechnol J. 2011 Feb;6(2):138-49. doi: 10.1002/biot.201000427.
Abstract
Low-cost, robust, and user-friendly diagnostic capabilities at the point-of-care (POC) are critical for treating infectious diseases and preventing their spread in developing countries. Recent advances in micro- and nanoscale technologies have enabled the merger of optical and fluidic technologies (optofluidics) paving the way for cost-effective lensless imaging and diagnosis for POC testing in resource-limited settings. Applications of the emerging lensless imaging technologies include detecting and counting cells of interest, which allows rapid and affordable diagnostic decisions. This review presents the advances in lensless imaging and diagnostic systems, and their potential clinical applications in developing countries. The emerging technologies are reviewed from a POC perspective considering cost effectiveness, portability, sensitivity, throughput and ease of use for resource-limited settings.
摘要
在医疗保健点（POC）实现低成本、稳健且易于使用的诊断功能对于治疗传染病和防止其在发展中国家传播至关重要。微纳尺度技术的最新进展使得光学和流体技术（光流控技术）得以融合，为在资源有限的环境中实现经济高效的无透镜成像和诊断铺平了道路。新兴无透镜成像技术的应用包括检测和计数感兴趣的细胞，从而可以快速做出经济实惠的诊断决策。本综述介绍了无透镜成像和诊断系统的最新进展，以及它们在发展中国家的潜在临床应用。从 PO C 的角度出发，考虑成本效益、便携性、灵敏度、吞吐量和易于使用性等因素，对新兴技术进行了评估。
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