Immune Disease Institute, the Program in Cellular and Molecular Medicine, Childrens Hospital Boston, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.
Nat Rev Mol Cell Biol. 2011 Mar;12(3):198-202. doi: 10.1038/nrm3060. Epub 2011 Feb 9.
In contrast to postmitotic or short-lived somatic cells, tissue-specific stem cells must persist and function throughout life to ensure tissue homeostasis and repair. The enormous functional demands and longevity of stem cells raises the possibility that stem cells might be uniquely equipped to maintain genomic integrity in ways different than somatic cells. Indeed, evidence suggests that stem cell compartments possess unique properties that combine to either limit or, in some instances, accelerate DNA damage accrual.
与有丝分裂后或寿命短的体细胞不同，组织特异性干细胞必须在整个生命过程中持续存在并发挥功能，以确保组织内稳态和修复。干细胞的巨大功能需求和寿命延长，使得干细胞有可能以不同于体细胞的方式来维持基因组完整性。事实上，有证据表明，干细胞区室具有独特的特性，这些特性结合起来，要么限制，要么在某些情况下加速 DNA 损伤的积累。
