Department of Medical Statistics, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany.
Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1129-36. doi: 10.1007/s00417-011-1619-7. Epub 2011 Feb 9.
To identify risk factors associated with best-corrected visual acuity (BCVA) 1 year after initial surgery following primary vitrectomy (PV) and scleral buckling surgery (SB) for rhegmatogenous retinal detachment (RRD).
Relating the final BCVA at the 1-year follow-up visit to pre- and intraoperative findings in the "randomized, prospective, multicenter clinical trial comparing scleral buckling versus primary vitrectomy for repair of rhegmatogenous retinal detachment" (SPR Study) using multivariate statistical methods.
In the phakic subtrial, final BCVA is associated with the number of breaks (p = 0.0259), duration of symptoms (p = 0.0476), baseline BCVA (p = 0.0002), retinal detachment central to major vessels arcades (p = 0.0088), total detachment (p = 0.0027), and chain formation of breaks (p = 0.0129). In the pseudophakic/aphakic subtrial, final BCVA is related to the number of retinal breaks (p = 0.0010), secondary cataract or central capsular fibrosis (p = 0.0141), intraoperative laser photocoagulation (p = 0.0373), and inferior detachment with breaks below the 4 and 8 o'clock positions (p = 0.0173).
Final BCVA is the most important outcome for patients undergoing RRD surgery. Our results demonstrate that the final BCVA is related to a higher preoperative number of breaks in both subtrials. Additional risk factors varied between phakic and pseudophakic subgroups.
确定原发性玻璃体切除术(PV)和巩膜扣带术(SB)治疗孔源性视网膜脱离(RRD)后初次手术后 1 年最佳矫正视力(BCVA)的相关危险因素。
在“比较巩膜扣带术与原发性玻璃体切除术治疗孔源性视网膜脱离的随机、前瞻性、多中心临床试验”(SPR 研究)中,使用多元统计方法将最终 BCVA 与 1 年随访时的术前和术中发现相关联。
在有晶状体亚组中,最终 BCVA 与裂孔数量(p = 0.0259)、症状持续时间(p = 0.0476)、基线 BCVA(p = 0.0002)、视网膜脱离中央至主要血管弓(p = 0.0088)、总脱离(p = 0.0027)和裂孔的链状形成(p = 0.0129)有关。在无晶状体/晶状体亚组中,最终 BCVA 与视网膜裂孔数量(p = 0.0010)、继发性白内障或中央囊膜纤维化(p = 0.0141)、术中激光光凝(p = 0.0373)以及 4 点和 8 点以下位置存在裂孔的下象限脱离(p = 0.0173)有关。
最终 BCVA 是接受 RRD 手术的患者最重要的结果。我们的结果表明,在两个亚组中,最终 BCVA 与术前裂孔数量较多有关。在有晶状体和无晶状体亚组之间,其他危险因素也有所不同。