Addor Flavia Alvim Sant'Anna, Schalka Sergio
Faculty of Medicine, University of Sao Paulo, Brazil.
An Bras Dermatol. 2010 Nov-Dec;85(6):789-95. doi: 10.1590/s0365-05962010000600003.
Adult female acne (AFA) is a dermatosis of increasing incidence; hyperandrogenism is present in many cases, but there are patients without hormonal abnormalities.
To analyze the prevalent characteristics in adult women with acne without hyperandrogenism.
A survey of 226 medical records with AFA complaints was conducted; of these, 116 (51.3%) had a normal hormonal profile and were, therefore, included in the study. We investigated age, ethnicity, clinical profile of acne, complementary exams, previous treatment, prescribed treatment and evolution.
The mean age was 33.9 years and the predominant clinical grade of acne was moderate inflammatory (grade 2). The face was the most affected area. Topical retinoids were the most prescribed drugs, and systemic medication was prescribed to 53.4% of the patients. Total regression was observed in 31 patients (26.7%) within 12 weeks of treatment. Adverse reactions to topical treatment occurred in 21.5% of the patients.
The clinical manifestations of AFA in patients without hyperandrogenism are moderate, with predominance of inflammatory lesions. Treatment is similar to that of acne vulgaris; however, special attention should be taken with more irritating medication since this group appears to be more predisposed to skin irritations.
成年女性痤疮(AFA)是一种发病率不断上升的皮肤病;许多病例存在高雄激素血症,但也有一些患者没有激素异常。
分析无高雄激素血症的成年女性痤疮患者的流行特征。
对226例有AFA症状的病历进行了调查;其中116例(51.3%)激素水平正常,因此纳入本研究。我们调查了年龄、种族、痤疮的临床特征、辅助检查、既往治疗、处方治疗及病情演变。
平均年龄为33.9岁,痤疮的主要临床分级为中度炎症性(2级)。面部是受影响最严重的部位。外用维甲酸是最常用的药物,53.4%的患者使用了全身用药。31例患者(26.7%)在治疗12周内完全消退。21.5%的患者出现局部治疗不良反应。
无高雄激素血症的AFA患者临床表现为中度,以炎性皮损为主。治疗与寻常痤疮相似;然而,对于刺激性较强的药物应特别注意,因为这组患者似乎更容易出现皮肤刺激反应。