Rocha Marco, Sanudo Adriana, Bagatin Edileia
Escola Paulista de Medicina - Universidade Federal de São Paulo (EPM-Unifesp), Brazil.
Dermatoendocrinol. 2017 Oct 13;9(1):e1361572. doi: 10.1080/19381980.2017.1361572. eCollection 2017.
Acne vulgaris is a chronic inflammatory disease that affects the pilosebaceous unit. Recent studies have shown an increasing number of cases of acne in adult women. These cases are predominantly normoandrogenic and have show some clinical differences compared to adolescent acne. In addition to the physical aspects, acne has a strong psychosocial impact and can lead to the onset of signs and symptoms of depression, such as anger. Our objective was to evaluate the effect on acne-specific quality of life in adult women treated with topical azelaic acid versus a combined oral contraceptive. The study population consisted of 38 adult women with acne and without any features of hyperandrogenism recruited from the clinic of Dermatology Hospital Division of São Paulo, Federal University of São Paulo from January 2012 to September 2014. Patients were randomized into two different groups: one receiving containing 20 ug of ethinylestradiol and 3 mg drospirenone in a regimen of 24 days of medication, a combined oral contraceptive (COC), and the other group topical 15% azelaic acid (AA) gel, twice daily, both for six months. The quality of life was evaluated at baseline and end of treatment with an acne specific measure (Acne-QoL). Before treatment, our data revealed a significant impact of the presence of acne on quality of life. Both treatments resulted in improvement with significant statistical values in quality of life scores. Comparing the four domains of Acne-QoL, patients treated with an oral contraceptive showed greater improvement in two domains (self-perception and acne symptoms) than those treated with azelaic acid.
寻常痤疮是一种影响毛囊皮脂腺单位的慢性炎症性疾病。最近的研究表明，成年女性痤疮病例数量不断增加。这些病例主要是正常雄激素性的，与青少年痤疮相比有一些临床差异。除了身体方面，痤疮还具有强烈的心理社会影响，可导致抑郁的体征和症状出现，如愤怒。我们的目的是评估外用壬二酸与复方口服避孕药治疗成年女性对痤疮特异性生活质量的影响。研究人群包括2012年1月至2014年9月从圣保罗联邦大学圣保罗皮肤科医院诊所招募的38名患有痤疮且无任何高雄激素特征的成年女性。患者被随机分为两组：一组接受含20μg炔雌醇和3mg屈螺酮、服药24天的复方口服避孕药（COC），另一组接受15%壬二酸（AA）凝胶，每天两次，均治疗六个月。在基线和治疗结束时用痤疮特异性测量方法（痤疮生活质量量表，Acne-QoL）评估生活质量。治疗前，我们的数据显示痤疮的存在对生活质量有显著影响。两种治疗均使生活质量得分有显著统计学意义的改善。比较痤疮生活质量量表的四个领域，口服避孕药治疗的患者在两个领域（自我认知和痤疮症状）的改善比壬二酸治疗的患者更大。
