Michel O, Dressler A K
Vrije Universiteit Brussel, Universitair Ziekenhuis Dienst KNO, Brüssel, Belgium.
Laryngorhinootologie. 2011 Apr;90(4):206-10. doi: 10.1055/s-0031-1271654. Epub 2011 Feb 9.
In several in-vitro research studies was shown that hypertonic salt water solution has an enhancing effect on mucociliary beat frequency. Nevertheless nose sprays with isotonic salt water solution are more popular on the market. They are sold as wellness products but also for care and cure of various nose diseases.
In a randomized double-blind trial with n = 20 healthy volunteers the effect of a 7-day application of hypertonic sodium chloride solution (3% NaCl) measured by saccharine-clearance-test (SCT), rhinomanometry and questionnaires was evaluated in comparison to a isotonic salt solution (0,9% NaCl).
The SCT showed in both groups no significant change. In rhinomanometry a significant higher rate of airflow could be measured after a 7 day period of applicating hypertonic spray. The volunteers evaluated the hypertonic solution as "more effective" in regard their nasal airflow.
Although in this RCT an effect on mucociliary clearance could not be detected after a 7 day application of salt water nose spray, a hypertonic spray showed objectively and subjectively a significant influence on nasal airflow. This effect could be of interest eg. in reducing the use of decongestive nose sprays.
多项体外研究表明，高渗盐水溶液对黏液纤毛摆动频率有增强作用。然而，市场上以等渗盐水溶液制成的鼻喷雾剂更受欢迎。它们作为保健品出售，也用于各种鼻部疾病的护理和治疗。
在一项有20名健康志愿者参与的随机双盲试验中，通过糖精清除试验（SCT）、鼻阻力测量法和问卷调查，评估了与等渗盐溶液（0.9%氯化钠）相比，高渗氯化钠溶液（3%氯化钠）7天应用的效果。
SCT显示两组均无显著变化。鼻阻力测量法显示，在使用高渗喷雾剂7天后，可以测量到显著更高的气流速率。志愿者们认为高渗溶液对他们的鼻腔气流“更有效”。
尽管在这项随机对照试验中，使用盐水鼻喷雾剂7天后未检测到对黏液纤毛清除功能的影响，但高渗喷雾剂在客观和主观上都对鼻腔气流有显著影响。例如，这种效果可能在减少使用减充血鼻喷雾剂方面具有意义。
