黑柴龙树对四氧嘧啶诱导的Wistar大鼠1型糖尿病和正细胞正色素性贫血的抗糖尿病及补血作用
Antidiabetic and haematinic effects of Parquetina nigrescens on alloxan induced type-1 diabetes and normocytic normochromic anaemia in Wistar rats.
作者信息
Saba A B, Oyagbemi A A, Azeez O I
机构信息
Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Nigeria.
出版信息
Afr Health Sci. 2010 Sep;10(3):276-82.
BACKGROUND
The plant, Parquetina nigrescens is used in folklore medicine to treat diabetes mellitus and its complications in several parts of West Africa.
OBJECTIVE
To determine the effect of Parquetina nigrescens extract on fasting blood glucose in alloxan-induced diabetic rats.
METHODS
The blood glucose levels, complete blood count, erythrocyte indices and osmotic fragility, body and organ weights were evaluated.
RESULTS
Diabetic rats treated with the extract showed significant (P<0.01) reduction of the blood glucose to levels comparable to that of the non-diabetic control and those treated with chlorpropamide (standard drug). Similarly, there was significant (P<0.01) reduction in the complete blood count in the diabetic rats.
DISCUSSION
The anaemia, leucopenia and thrombocytopenia associated with the diabetes were corrected in the animals treated with the extract and chlorpropamide. The extract also reduced the erythrocyte osmotic fragility, body and organ weights. Parquetina nigrescens demonstrated antidiabetic property by reducing the elevated blood glucose in alloxan treated rats which is comparable to animals that received the standard drug.
CONCLUSION
Paraquetina nigrescens stabilized the erythrocyte membrane, decreased the body weight probably by lowering lipogenesis. However, the mechanism underlying the antidiabetic and haematinic properties of Parquetina nigrescens remains to be elucidated.
背景
在西非的几个地区，黑叶帕奎草在民间医学中被用于治疗糖尿病及其并发症。
目的
确定黑叶帕奎草提取物对四氧嘧啶诱导的糖尿病大鼠空腹血糖的影响。
方法
评估血糖水平、全血细胞计数、红细胞指数和渗透脆性、体重和器官重量。
结果
用提取物治疗的糖尿病大鼠血糖显著降低（P<0.01），降至与非糖尿病对照组和用氯磺丙脲（标准药物）治疗的大鼠相当的水平。同样，糖尿病大鼠的全血细胞计数也显著降低（P<0.01）。
讨论
用提取物和氯磺丙脲治疗的动物纠正了与糖尿病相关的贫血、白细胞减少和血小板减少。提取物还降低了红细胞渗透脆性、体重和器官重量。黑叶帕奎草通过降低四氧嘧啶处理大鼠的血糖升高表现出抗糖尿病特性，这与接受标准药物的动物相当。
结论
黑叶帕奎草稳定了红细胞膜，可能通过降低脂肪生成减少了体重。然而，黑叶帕奎草抗糖尿病和补血特性的潜在机制仍有待阐明。
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