Division of Epidemiology and CommunityHealth,University ofMinnesota,Minneapolis,Minnesota, USA.
Diabetes Care. 2011 Apr;34(4):880-5. doi: 10.2337/dc10-2350. Epub 2011 Feb 17.
To empirically derive dietary patterns and examine their association with incident type 2 diabetes.
We used data from the Singapore Chinese Health Study, including 43,176 Chinese men and women (aged 45-74 years), free of diabetes, cardiovascular disease, and cancer at baseline (1993-1998) and followed up through 2004. Two major dietary patterns were identified using principal components analysis: a vegetable, fruit, and soy-rich pattern (VFS) and a dim sum and meat-rich pattern (DSM). Pattern scores for each participant were calculated and examined with type 2 diabetes risk using Cox regression.
The associations of the two dietary patterns with diabetes risk were modified by smoking status. Neither pattern was associated with risk of diabetes in ever smokers. In never smokers, the VFS dietary pattern was inversely associated with risk of type 2 diabetes. Compared with the lowest quintile of the VFS dietary pattern score, the hazard ratios (HRs) for quintiles 2-5 were 0.91, 0.82, 0.73, and 0.75 (P = 0.0005 for trend). The DSM dietary pattern was positively associated with risk of type 2 diabetes in never smokers, with HRs for quintiles 2-5 of 1.07, 1.25, 1.18, and 1.47 (P < 0.0001 for trend).
A dietary pattern with higher intake of vegetables, fruits, and soy foods was inversely associated with risk of incident type 2 diabetes, and a pattern with higher intake of dim sum, meat and processed meat, sweetened foods and beverages, and fried foods was associated with a significantly increased risk of type 2 diabetes in Chinese men and women in Singapore.
从经验上得出饮食模式，并研究其与 2 型糖尿病发病的关系。
我们使用了来自新加坡华人健康研究的数据，包括 43176 名年龄在 45-74 岁之间、基线时无糖尿病、心血管疾病和癌症的中国男女（1993-1998 年），并随访至 2004 年。使用主成分分析识别出两种主要的饮食模式：富含蔬菜、水果和大豆的模式（VFS）和富含点心和肉类的模式（DSM）。为每个参与者计算模式得分，并使用 Cox 回归分析与 2 型糖尿病风险进行检查。
两种饮食模式与糖尿病风险的关系受到吸烟状况的修饰。在现吸烟者中，这两种模式均与糖尿病风险无关。在从不吸烟者中，VFS 饮食模式与 2 型糖尿病的发病风险呈负相关。与 VFS 饮食模式得分最低的五分位数相比，五分位数 2-5 的危险比（HR）分别为 0.91、0.82、0.73 和 0.75（趋势 P = 0.0005）。在从不吸烟者中，DSM 饮食模式与 2 型糖尿病的发病风险呈正相关，五分位数 2-5 的 HR 分别为 1.07、1.25、1.18 和 1.47（趋势 P < 0.0001）。
富含蔬菜、水果和大豆的饮食模式与 2 型糖尿病发病风险呈负相关，而富含点心、肉类和加工肉类、甜食和饮料以及油炸食品的饮食模式与新加坡中国男女 2 型糖尿病发病风险显著增加相关。
