Barreto Fs, Sousa Eo, Campos Ar, Costa Jgm, Rodrigues Ffg
Departamento de Química-Biológica, Laboratório de Pesquisa de Produtos Naturais, Universidade Regional do Cariri, Rua Cel. Antônio Luiz 1161, Pimenta, 63105 - 000, Crato-CE, Brazil.
J Young Pharm. 2010 Jan;2(1):42-4. doi: 10.4103/0975-1483.62211.
The use of medicinal plants with therapeutics properties represents a secular tradition in different cultures, mainly in underdeveloped countries. Lantana camara Linn and Lantana montevidensis Briq (Verbenaceae) found in tropical and subtropical areas around the world are popularly known as "camará" or "chumbinho." In popular medicines, both plants are used as antipyretic and carminative and in the treatment of respiratory system infections. In this study, the antibacterial activity of the ethanolic extracts of L. camara and L. montevidensis leaves and roots against gram-positive and gram-negative strains standard and multi-resistant bacteria isolated from clinical material are presented. In order to determine the minimal inhibitory concentration (MIC), the microdilution method was used. The extracts demonstrated antibacterial activity against all tested bacteria, but the L. montevidensis fresh leaves extract present the best result against P. aeruginosa (MIC 8 μg/mL) and against multi-resistant E. coli (Ec 27) (MIC 16 μg/mL). These results drive new researches with both species in order to isolate the constituents responsible for the activity.
使用具有治疗特性的药用植物在不同文化中都是一种由来已久的传统，在欠发达国家尤为如此。在世界各地热带和亚热带地区发现的马缨丹（Lantana camara Linn）和蔓马缨丹（Lantana montevidensis Briq）（马鞭草科），通常被称为“卡马拉”或“小臭草”。在民间药物中，这两种植物都被用作退烧药、驱风剂，并用于治疗呼吸系统感染。在本研究中，展示了马缨丹和蔓马缨丹叶与根的乙醇提取物对从临床材料中分离出的革兰氏阳性和革兰氏阴性标准菌株及多重耐药菌的抗菌活性。为了确定最低抑菌浓度（MIC），采用了微量稀释法。提取物对所有测试细菌均表现出抗菌活性，但蔓马缨丹新鲜叶提取物对铜绿假单胞菌（MIC 8 μg/mL）和多重耐药大肠杆菌（Ec 27）（MIC 16 μg/mL）的效果最佳。这些结果推动了对这两个物种的新研究，以分离出具有该活性的成分。
