• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds.氮氧自由基修饰的 2-氨基-7-溴芴的合成与研究及其前体作为双重抗淀粉样蛋白和抗氧化活性化合物。
Eur J Med Chem. 2011 Apr;46(4):1348-55. doi: 10.1016/j.ejmech.2011.01.059. Epub 2011 Feb 3.
2
Synthesis and study of new paramagnetic and diamagnetic verapamil derivatives.合成与研究新的顺磁和反磁维拉帕米衍生物。
Bioorg Med Chem. 2010 Apr 15;18(8):2954-63. doi: 10.1016/j.bmc.2010.02.040. Epub 2010 Feb 25.
3
Aromatic and aliphatic mono- and bis-nitroxides: a study on their radical scavenging abilities.芳香族和脂肪族单硝基氧化物及双硝基氧化物：关于其自由基清除能力的研究。
Free Radic Res. 2005 Mar;39(3):325-36. doi: 10.1080/10715760400028019.
4
Synthesis of alpha-aryl N-adamant-1-yl nitrones and using them for spin trapping of hydroxyl radicals.α-芳基 N-金刚烷-1-基硝酮的合成及其用于羟基自由基的自旋捕获
Bioorg Med Chem Lett. 1998 Feb 17;8(4):379-84. doi: 10.1016/s0960-894x(98)00033-x.
5
Novel 2-substituted nitronyl nitroxides as free radical scavengers: synthesis, biological evaluation and structure-activity relationship.新型2-取代硝酮自由基清除剂：合成、生物学评价及构效关系
Bioorg Med Chem. 2006 Aug 15;14(16):5711-20. doi: 10.1016/j.bmc.2006.04.016. Epub 2006 May 2.
6
Kinetics and mechanism of hydroxyl radical and OH-adduct radical reactions with nitroxides and with their hydroxylamines.羟基自由基和OH-加合物自由基与氮氧化物及其羟胺反应的动力学和机理。
J Am Chem Soc. 2002 Jul 24;124(29):8719-24. doi: 10.1021/ja017587h.
7
ESR and HPLC-EC analysis of the interaction of hydroxyl radical with DMSO: rapid reduction and quantification of POBN and PBN nitroxides.羟基自由基与二甲基亚砜相互作用的红细胞沉降率及高效液相色谱-电化学分析：POBN和PBN氮氧化物的快速还原与定量分析
Anal Chem. 1999 Feb 1;71(3):715-21. doi: 10.1021/ac980657r.
8
The use of cyclic nitroxide radicals as HNO scavengers.作为 HNO 清除剂的环状硝氧自由基的应用。
J Inorg Biochem. 2013 Jan;118:155-61. doi: 10.1016/j.jinorgbio.2012.10.002. Epub 2012 Oct 12.
9
Role of allyl group in the hydroxyl and peroxyl radical scavenging activity of S-allylcysteine.烯丙基基团在 S-烯丙半胱氨酸清除羟自由基和过氧自由基活性中的作用。
J Phys Chem B. 2011 Nov 17;115(45):13408-17. doi: 10.1021/jp208233f. Epub 2011 Oct 26.
10
Synthesis and ESR study of new dihydroxamic acid siderophores S as scavengers of hydroxyl radicals.新型异羟肟酸类铁载体S作为羟基自由基清除剂的合成及电子自旋共振研究
Bioorg Med Chem Lett. 1998 Feb 3;8(3):227-32. doi: 10.1016/s0960-894x(97)10219-0.

引用本文的文献

1
Fluorimetric Detection of Insulin Misfolding by Probes Derived from Functionalized Fluorene Frameworks.荧光法检测荧光芴骨架功能化探针诱导的胰岛素错误折叠
Molecules. 2024 Mar 7;29(6):1196. doi: 10.3390/molecules29061196.
2
Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer's Disease.功能性食品：调节阿尔茨海默病分子机制的一种方法。
Cells. 2020 Oct 23;9(11):2347. doi: 10.3390/cells9112347.
3
Mitochondrial oxidative stress-induced transcript variants of ATF3 mediate lipotoxic brain microvascular injury.线粒体氧化应激诱导的ATF3转录变体介导脂毒性脑微血管损伤。
Free Radic Biol Med. 2019 Nov 1;143:25-46. doi: 10.1016/j.freeradbiomed.2019.07.024. Epub 2019 Jul 26.
4
Oligomerization Alters Binding Affinity Between Amyloid Beta and a Modulator of Peptide Aggregation.寡聚化改变了淀粉样β蛋白与肽聚集调节剂之间的结合亲和力。
J Phys Chem C Nanomater Interfaces. 2017 Nov 2;121(43):23974-23987. doi: 10.1021/acs.jpcc.7b06164. Epub 2017 Oct 10.
5
A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta.一种双功能抗淀粉样蛋白可阻断氧化应激和细胞内淀粉样β蛋白的积累。
Molecules. 2018 Aug 12;23(8):2010. doi: 10.3390/molecules23082010.
6
A Metal-Free Method for Producing MRI Contrast at Amyloid-β.一种用于在β-淀粉样蛋白处产生磁共振成像造影剂的无金属方法。
J Alzheimers Dis. 2017;55(4):1667-1681. doi: 10.3233/JAD-160279.
7
Protective spin-labeled fluorenes maintain amyloid beta peptide in small oligomers and limit transitions in secondary structure.具有保护作用的自旋标记芴可使β-淀粉样肽维持在小寡聚体状态，并限制其二级结构转变。
Biochim Biophys Acta. 2015 Dec;1854(12):1860-1870. doi: 10.1016/j.bbapap.2015.09.002. Epub 2015 Sep 14.
8
A systems biology analysis of brain microvascular endothelial cell lipotoxicity.脑微血管内皮细胞脂毒性的系统生物学分析
BMC Syst Biol. 2014 Jul 4;8:80. doi: 10.1186/1752-0509-8-80.
9
Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors.用氮氧化物或其前体修饰的新型他克林类似物的合成与功能研究。
Eur J Med Chem. 2014 Apr 22;77:343-50. doi: 10.1016/j.ejmech.2014.03.026. Epub 2014 Mar 12.
10
The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide.芳基取代的氮氧自由基化合物对淀粉样β肽聚集及毒性的影响。
PLoS One. 2012;7(4):e35443. doi: 10.1371/journal.pone.0035443. Epub 2012 Apr 30.

本文引用的文献

1
Synthesis and study of new paramagnetic and diamagnetic verapamil derivatives.合成与研究新的顺磁和反磁维拉帕米衍生物。
Bioorg Med Chem. 2010 Apr 15;18(8):2954-63. doi: 10.1016/j.bmc.2010.02.040. Epub 2010 Feb 25.
2
Mechanisms underlying inflammation in neurodegeneration.神经变性中炎症的发生机制。
Cell. 2010 Mar 19;140(6):918-34. doi: 10.1016/j.cell.2010.02.016.
3
Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation.纤维状寡聚物启动单体淀粉样β的寡聚化，但不引发纤维形成。
J Biol Chem. 2010 Feb 26;285(9):6071-9. doi: 10.1074/jbc.M109.069542. Epub 2009 Dec 15.
4
Alzheimer's disease: from pathology to therapeutic approaches.阿尔茨海默病：从病理学到治疗方法
Angew Chem Int Ed Engl. 2009;48(17):3030-59. doi: 10.1002/anie.200802808.
5
Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents.从淀粉样蛋白成像剂类似物中筛选出候选抗 Aβ 芴类化合物。
Neurobiol Aging. 2010 Oct;31(10):1690-9. doi: 10.1016/j.neurobiolaging.2008.09.019. Epub 2008 Nov 20.
6
Nitric oxide and nitroxides can act as efficient scavengers of protein-derived free radicals.一氧化氮和氮氧化物可作为蛋白质衍生自由基的有效清除剂。
Chem Res Toxicol. 2008 Nov;21(11):2111-9. doi: 10.1021/tx800183t.
7
Reversible reduction of nitroxides to hydroxylamines: roles for ascorbate and glutathione.氮氧化物可逆还原为羟胺：抗坏血酸和谷胱甘肽的作用
Free Radic Biol Med. 2007 Feb 1;42(3):404-12. doi: 10.1016/j.freeradbiomed.2006.11.007. Epub 2006 Nov 10.
8
Exploring interaction of beta-amyloid segment (25-35) with membrane models through paramagnetic probes.通过顺磁探针探索β-淀粉样蛋白片段（25-35）与膜模型的相互作用。
J Pept Sci. 2006 Dec;12(12):766-74. doi: 10.1002/psc.811.
9
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.神经退行性疾病中的线粒体功能障碍与氧化应激
Nature. 2006 Oct 19;443(7113):787-95. doi: 10.1038/nature05292.
10
Inhibitory activity of stilbenes on Alzheimer's beta-amyloid fibrils in vitro.芪类化合物对阿尔茨海默病β-淀粉样蛋白原纤维的体外抑制活性。
Bioorg Med Chem. 2007 Jan 15;15(2):1160-7. doi: 10.1016/j.bmc.2006.09.069. Epub 2006 Oct 1.

氮氧自由基修饰的 2-氨基-7-溴芴的合成与研究及其前体作为双重抗淀粉样蛋白和抗氧化活性化合物。

Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds.

机构信息

Institute of Organic and Medicinal Chemistry, University of Pécs, Szigeti st 12, H-7624 Pécs, Hungary.

出版信息

Eur J Med Chem. 2011 Apr;46(4):1348-55. doi: 10.1016/j.ejmech.2011.01.059. Epub 2011 Feb 3.

DOI:10.1016/j.ejmech.2011.01.059
PMID:21333407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3650846/
Abstract

A series of 2-aminofluorenes N-alkylated with nitroxides or their precursors were synthesized. The new compounds were tested on hydroxyl radical and peroxyl radical scavenging ability and inflammatory assay on the endothelial brain cells. In agreement with ROS scavenging ability the same compound 7-bromo-N -[(1-Oxyl-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine-4yl)methyl]-9H-fluoren-2-amine (3b) and its hydroxylamine salt (3b/OH/HCl) showed the anti-inflammatory property on the endothelial brain cells.

摘要

合成了一系列被氮氧自由基或其前体烷化的 2-氨基芴。新化合物的羟基自由基和过氧自由基清除能力以及对内皮脑细胞的炎症反应进行了测试。与 ROS 清除能力一致，相同的化合物 7-溴-N -[(1-氧代-2,2,6,6-四甲基-1,2,3,6-四氢吡啶-4-基)甲基]-9H-芴-2-胺（3b）及其羟胺盐（3b/OH/HCl）在对内皮脑细胞显示出抗炎特性。