Department of Ophthalmology, Justus-Liebig-University Giessen, Universitätsklinikum Giessen & Marburg GmbH, Giessen Campus, Friedrichstr. 18, 35392 Giessen, Germany.
Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1137-45. doi: 10.1007/s00417-011-1630-z. Epub 2011 Feb 20.
To evaluate in healthy eyes the interchangeability of retinal thickness measurements resulting from different protocols of Spectralis optical coherence tomography (OCT, Heidelberg Engineering, Germany).
Three different central volumetric protocols were performed in one session by one single operator in a randomly selected eye of 31 healthy adults (range, 19-30 years): (1) area 6 × 6 mm, 25 scan pattern (SP), (2) area 6 × 6 mm, 49 SP, (3) area 6 × 3 mm, 97 SP. Nine ETDRS areas were analyzed, except outer areas for 97 SP. Interclass correlation coefficients (ICC) and limits of agreement (Bland-Altman) were calculated.
Mean minimal foveal thickness was 224.0 ± 15.8 μm and central retinal thickness 280.8 ± 16.5 μm. ICC ranged from 0.973 to 0.993. Ninety-five percent limits of agreement between the protocols were <7 μm in all ETDRS areas. The difference between two measurements never exceeded 9 μm.
Spectralis OCT retinal thickness measurements in healthy subjects showed good protocol interchangeability for all tested protocols. Larger differences are to be expected in eyes with macular pathology.
评估不同 Spectralis 光学相干断层扫描（OCT）协议得出的视网膜厚度测量值在健康眼中是否具有可互换性。
由同一位操作者在 31 名健康成年人（年龄 19-30 岁）的随机一只眼中一次完成三种不同的中心容积协议：（1）6×6mm 面积，25 个扫描模式（SP）；（2）6×6mm 面积，49 个 SP；（3）6×3mm 面积，97 个 SP。分析了 9 个 ETDRS 区域，对于 97 SP 则不分析外区域。计算了组内相关系数（ICC）和一致性界限（Bland-Altman）。
平均最小中心凹厚度为 224.0±15.8μm，中心视网膜厚度为 280.8±16.5μm。ICC 范围为 0.973 至 0.993。所有 ETDRS 区域中，两种协议之间的 95%一致性界限差异均<7μm。两次测量之间的差异从未超过 9μm。
在健康受试者中，Spectralis OCT 视网膜厚度测量值对于所有测试协议均显示出良好的协议可互换性。在有黄斑病变的眼睛中，预计会有更大的差异。
