Department of Psychiatry, Johns Hopkins University, School of Medicine, 5200 Eastern Avenue, Suite 142 West, Baltimore, MD 21224, USA.
Exp Clin Psychopharmacol. 2011 Feb;19(1):20-30. doi: 10.1037/a0022039.
Cigarette smoking is highly prevalent among patients who are being treated for opioid-dependence, yet there have been limited scientific efforts to promote smoking cessation in this population. Contingency management (CM) is a behavioral treatment that provides monetary incentives contingent upon biochemical evidence of drug abstinence. This paper discusses the results of two studies that utilized CM to promote brief smoking cessation among opioid-maintained patients. Participants in a pilot study were randomly assigned for a 2-week period to a Contingent group that earned monetary vouchers for providing biochemical samples that met criteria for smoking abstinence, or a Noncontingent group that earned monetary vouchers independent of smoking status (Dunn et al., 2008). Results showed Contingent participants provided significantly more smoking-negative samples than Noncontingent participants (55% vs. 5%, respectively). A second randomized trial that utilized the same 2-week intervention and provided access to the smoking cessation pharmacotherapy bupropion replicated the results of the pilot study (55% and 17% abstinence in Contingent and Noncontingent groups, respectively; Dunn et al, 2010). Relapse to illicit drug use was also evaluated prospectively and no association between smoking abstinence and relapse to illicit drug use was observed (Dunn et al., 2009). It will be important for future studies to evaluate participant characteristics that might predict better treatment outcome, to assess the contribution that pharmacotherapies might have alone or in combination with a CM intervention on smoking cessation and to evaluate methods for maintaining the abstinence that is achieved during this brief intervention for longer periods of time.
吸烟在接受阿片类药物依赖治疗的患者中非常普遍,但在该人群中促进戒烟的科学努力有限。 条件管理 (CM) 是一种行为治疗方法,根据药物戒断的生化证据提供金钱奖励。 本文讨论了两项利用 CM 促进阿片类药物维持患者短暂戒烟的研究结果。 一项试点研究中的参与者被随机分配在 2 周内接受有条件组或无条件组。 有条件组通过提供符合戒烟标准的生化样本赚取金钱券,而无条件组则独立于吸烟状况赚取金钱券(Dunn 等人,2008 年)。 结果表明,有条件组参与者提供的吸烟阴性样本明显多于无条件组参与者(分别为 55%和 5%)。 第二项随机试验使用相同的 2 周干预措施并提供戒烟药物治疗安非他酮的使用机会,复制了试点研究的结果(分别有 55%和 17%的参与者在有条件组和无条件组中戒烟;Dunn 等人,2010 年)。 还前瞻性评估了非法药物使用的复发情况,未观察到吸烟戒断与非法药物使用复发之间的关联(Dunn 等人,2009 年)。 未来的研究将评估可能预测更好治疗结果的参与者特征,评估单独或联合 CM 干预对戒烟的药理学治疗的贡献,并评估在这种短暂干预期间实现的禁欲维持更长时间的方法将是重要的。