色素上皮脱离的多模态影像学：评估指南。

Multimodal imaging of pigment epithelial detachment: a guide to evaluation.

机构信息

*Vitreous Retina Macula Consultants of New York, New York, New York; †LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York; ‡Retinal Disorders and Ophthalmic Genetics Division, Jules Stein, Eye Institute, University of California, Los Angeles, California; and §Greater Los Angeles VA Healthcare Center, Los Angeles, California.

出版信息

Retina. 2013 Oct;33(9):1735-62. doi: 10.1097/IAE.0b013e3182993f66.

DOI:10.1097/IAE.0b013e3182993f66

PMID:23873168

Abstract

PURPOSE

To describe the spectrum of pigment epithelial detachments (PEDs) occurring mainly in age-related macular degeneration and central serous chorioretinopathy and also in other inflammatory, neoplastic and iatrogenic, retinal, and systemic disorders.

METHODS

Pigment epithelial detachments are divided into drusenoid, serous, vascularized, or mixed categories.

RESULTS

The clinical presentation, classification, and natural history of PEDs are reviewed as illustrated with multimodal imaging combining traditional and novel imaging techniques, including fluorescein angiography, indocyanine green angiography, fundus autofluorescence, and spectral domain optical coherence tomography. Most PEDs occur because of pathophysiologic mechanisms taking place below the retinal pigment epithelium that are difficult to identify with conventional imaging modalities. Enhanced depth imaging optical coherence tomography and indocyanine green angiography allow a better analysis of the subretinal pigment epithelium compartment.

CONCLUSION

The differentiation between various kinds of PEDs is essential because each PED type is a distinct entity that has a specific pathogenesis, natural history, prognosis, and optimal treatment strategy.

摘要

目的

描述主要发生于年龄相关性黄斑变性和中心性浆液性脉络膜视网膜病变，以及其他炎症、肿瘤和医源性、视网膜和系统性疾病中的色素上皮脱离（PED）的光谱。

方法

PED 分为玻璃膜疣样、浆液性、血管性或混合性。

结果

结合传统和新型成像技术（包括荧光素血管造影、吲哚青绿血管造影、眼底自发荧光和谱域光相干断层扫描）对 PED 的临床表现、分类和自然史进行了综述。大多数 PED 是由于视网膜色素上皮下发生的病理生理机制引起的，这些机制很难用常规成像方式识别。增强深度成像光相干断层扫描和吲哚青绿血管造影可更好地分析视网膜色素上皮下间隙。