Department of Psychiatry, University of Arizona, Tucson, AZ, USA.
J Clin Sleep Med. 2011 Feb 15;7(1):93-4.
Circadian rhythm sleep disorder, free-running type (CRSD, FRT) is a disorder in which the intrinsic circadian rhythm is no longer entrained to the 24-hour schedule. A unique case of CRSD, FRT in a 67-year-old sighted male is presented. The patient had a progressively delayed time in bed (TIB) each night, so that he would cycle around the 24-h clock approximately every 30 days. This was meticulously documented each night by the patient over the course of 22 years. The patient's CRSD, FRT was associated with severe depression, anxiety, and agoraphobia. The agoraphobia may have exacerbated the CRSD, FRT. Entrainment and stabilization of his circadian rhythm was accomplished after treatment that included melatonin, light therapy, and increased sleep structure.
昼夜节律睡眠障碍，自由运行型（CRSD，FRT）是一种内在的昼夜节律不再与 24 小时的日程同步的疾病。介绍了一位 67 岁有视力的男性中独特的 CRSD，FRT 病例。患者每晚的卧床时间（TIB）逐渐延迟，以至于他大约每 30 天就会围绕 24 小时钟循环一次。在 22 年的时间里，患者每晚都在认真记录。患者的 CRSD，FRT 与严重的抑郁、焦虑和广场恐怖症有关。广场恐怖症可能使 CRSD，FRT 恶化。在包括褪黑素、光照疗法和增加睡眠结构的治疗后，他的昼夜节律得到了同步和稳定。
