从东北马兜铃中分离得到的新型生物碱aristopyridinone A 和具有抗炎作用的菲类化合物。
A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis.
机构信息
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
出版信息
Bioorg Med Chem Lett. 2011 Mar 15;21(6):1792-4. doi: 10.1016/j.bmcl.2011.01.067. Epub 2011 Jan 22.
A novel alkaloid, aristopyridinone A (1) and a new phenanthrene, aristolamide II (2), were isolated from Aristolochia manshuriensis (Guanmutong) together with eight known phenanthrenes (3-10). All structures were elucidated by spectroscopic methods. Compound 2 showed a selective inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC(50) value of 4.11 μg/mL. Compound 7 exhibited significant inhibitory effects on superoxide anion generation and elastase release with IC(50) values of 0.12 and 0.20 μg/mL, respectively.
从东北马兜铃（关木通）中分离得到了一个新的生物碱aristopyridinone A（1）和一个新的菲衍生物 aristolamide II（2），以及另外 8 个已知的菲衍生物（3-10）。所有结构均通过光谱方法阐明。化合物 2 对人中性粒细胞响应 fMLP 释放弹性蛋白酶具有选择性抑制作用，IC50 值为 4.11 μg/mL。化合物 7 对超氧阴离子生成和弹性蛋白酶释放具有显著的抑制作用，IC50 值分别为 0.12 和 0.20 μg/mL。
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