利用处于第二振动模式的微通道谐振器进行高精度粒子质量传感。
High precision particle mass sensing using microchannel resonators in the second vibration mode.
作者信息
Lee Jungchul, Bryan Andrea K, Manalis Scott R
机构信息
Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
出版信息
Rev Sci Instrum. 2011 Feb;82(2):023704. doi: 10.1063/1.3534825.
An intrinsic uncertainty in particle mass sensing with the suspended microchannel resonator results from variation in a particle's position near the free end of the resonator. To circumvent this error we employ the second flexural bending mode. This mode exhibits additional frequency peaks while particles pass over the antinode, a point where the frequency shift is insensitive to the lateral position of the particle. We measure polystyrene beads with the first and second modes and confirm that the second mode sensing provides a narrower mass histogram. For 3 μm diameter beads, second mode sensing at the antinode improves the coefficient of variation in buoyant mass from 1.76% to 1.05% for population measurements and from 1.40% to 0.53% for a single trapped particle.
悬浮微通道谐振器在粒子质量传感方面存在内在的不确定性，这是由粒子在谐振器自由端附近位置的变化引起的。为了规避这种误差，我们采用了第二阶弯曲振动模式。当粒子经过波腹（频率偏移对粒子横向位置不敏感的点）时，该模式会出现额外的频率峰值。我们用第一阶和第二阶模式测量了聚苯乙烯珠子，并证实第二阶模式传感提供了更窄的质量直方图。对于直径为3μm的珠子，在波腹处进行第二阶模式传感时，对于群体测量，浮力质量的变异系数从1.76%提高到1.05%，对于单个捕获粒子，变异系数从1.40%提高到0.53%。
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