光学成像技术在癌症诊治中的应用：从术中手术指导到癌症筛查。
Current and future clinical applications for optical imaging of cancer: from intraoperative surgical guidance to cancer screening.
机构信息
Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
出版信息
Semin Oncol. 2011 Feb;38(1):109-18. doi: 10.1053/j.seminoncol.2010.11.008.
Abstract
Optical imaging is an inexpensive, fast, and sensitive imaging approach for the noninvasive detection of human cancers in locations that are accessible by an optical imaging device. Light is used to probe cellular and molecular function in the context of cancer in the living body. Recent advances in the development of optical instrumentation make it possible to detect optical signals produced at a tissue depth of several centimeters. The optical signals can be endogenous contrasts that capture the heterogeneity and biological status of different tissues, including tumors, or extrinsic optical contrasts that selectively accumulate in tumors to be imaged after local or systemic delivery. The use of optical imaging is now being applied in the clinic and operating room for the localization and resection of malignant tumors in addition to screening for cancer.
摘要
光学成像是一种经济、快速、灵敏的成像方法，可用于非侵入式检测人体癌症，这些癌症的位置可以通过光学成像设备进行检测。光被用于探测活体中癌症相关的细胞和分子功能。最近，光学仪器的发展取得了进展，使得能够探测到在几厘米组织深度产生的光学信号。光学信号可以是内源性对比，以捕获不同组织（包括肿瘤）的异质性和生物学状态，也可以是外源性对比，其选择性地在肿瘤中积累，以便在局部或全身给药后进行成像。除了癌症筛查之外，光学成像现在也被应用于临床和手术室，用于定位和切除恶性肿瘤。
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