主要基因对龋齿的抵抗力起控制作用。
A major gene effect controls resistance to caries.
机构信息
Core for Advanced Molecular Investigation, Graduate Program in Health Sciences, Center for Biological and Health Sciences, Pontifical Catholic University of Paraná, Imaculada Conceição St 1155 - CCBS/PPGCS, Prado Velho, CEP 80215-901 Curitiba, Paraná, Brazil.
出版信息
J Dent Res. 2011 Jun;90(6):735-9. doi: 10.1177/0022034510397614. Epub 2011 Mar 1.
Abstract
Despite recent advances revealing genetic factors influencing caries susceptibility, questions regarding the model of inheritance involved are yet to be addressed. We conducted a Complex Segregation Analysis on decayed teeth in a sample of homogenous, isolated families recruited from the Brazilian Amazon. A dominant, major gene effect controlling resistance to phenotype was detected. The frequency of the resistance allele "A" was 0.63; mean numbers of decayed teeth were 1.53 and 9.53 for genotypes AA/AB and BB, respectively. These results represent a step toward a description of the exact nature of the genetic risk factors controlling human susceptibility to caries.
摘要
尽管最近的研究进展揭示了影响龋齿易感性的遗传因素，但涉及的遗传模式仍有待解决。我们对从巴西亚马逊招募的同质、孤立家庭样本中的龋齿进行了复杂分离分析。检测到控制表型抗性的显性主基因效应。抗性等位基因“A”的频率为 0.63；基因型 AA/AB 和 BB 的平均龋齿数分别为 1.53 和 9.53。这些结果是朝着描述控制人类龋齿易感性的遗传风险因素的确切性质迈出的一步。
相似文献
1
A major gene effect controls resistance to caries.主要基因对龋齿的抵抗力起控制作用。
J Dent Res. 2011 Jun;90(6):735-9. doi: 10.1177/0022034510397614. Epub 2011 Mar 1.
2
GLUT2 and TAS1R2 Polymorphisms and Susceptibility to Dental Caries.葡萄糖转运蛋白2（GLUT2）和味觉受体1型成员2（TAS1R2）基因多态性与龋齿易感性
Caries Res. 2015;49(4):417-24. doi: 10.1159/000430958. Epub 2015 Jun 24.
3
Association of dental caries with HLA Class II allele in Brazilian adolescents.巴西青少年的龋病与 HLA Ⅱ类等位基因的相关性。
Caries Res. 2012;46(6):530-5. doi: 10.1159/000341188. Epub 2012 Aug 16.
4
Genetic susceptibility to dental caries differs between the sexes: a family-based study.基于家庭的研究：龋齿的遗传易感性存在性别差异。
Caries Res. 2015;49(2):133-40. doi: 10.1159/000369103. Epub 2015 Jan 22.
5
Common SNPs of AmelogeninX (AMELX) and dental caries susceptibility.AMELX 常见单核苷酸多态性与龋齿易感性的关系。
J Dent Res. 2013 May;92(5):418-24. doi: 10.1177/0022034513482941. Epub 2013 Mar 22.
6
Lack of association between lactotransferrin polymorphism and dental caries.乳铁传递蛋白多态性与龋齿之间无关联。
Caries Res. 2014;48(1):39-44. doi: 10.1159/000351689. Epub 2013 Nov 6.
7
Association of GLUT2 and TAS1R2 genotypes with risk for dental caries.GLUT2 和 TAS1R2 基因型与龋齿风险的关联。
Caries Res. 2013;47(3):219-25. doi: 10.1159/000345652. Epub 2012 Dec 19.
8
Genetic association for caries susceptibility among cleft lip and/or palate individuals.唇腭裂个体患龋易感性的基因关联研究。
J Contemp Dent Pract. 2014 May 1;15(3):288-93. doi: 10.5005/jp-journals-10024-1530.
9
Genome-wide association scan of dental caries in the permanent dentition.全基因组关联扫描分析恒牙龋齿
BMC Oral Health. 2012 Dec 21;12:57. doi: 10.1186/1472-6831-12-57.
10
Heritable patterns of tooth decay in the permanent dentition: principal components and factor analyses.恒牙龋病的遗传模式：主成分和因子分析。
BMC Oral Health. 2012 Mar 9;12:7. doi: 10.1186/1472-6831-12-7.
引用本文的文献
1
A study on genetic and mutans streptococcal transmissibility of dental caries.一项关于龋齿的遗传及变形链球菌传播性的研究。
J Oral Maxillofac Pathol. 2022 Oct-Dec;26(4):604. doi: 10.4103/jomfp.jomfp_201_22. Epub 2022 Dec 22.
2
Deficiency of Mineralization-Regulating Transcription Factor Trps1 Compromises Quality of Dental Tissues and Increases Susceptibility to Dental Caries.矿化调节转录因子Trps1的缺乏会损害牙组织质量并增加患龋齿的易感性。
Front Dent Med. 2022;3. doi: 10.3389/fdmed.2022.875987. Epub 2022 Apr 11.
3
NOD2 and CCDC122-LACC1 genes are associated with leprosy susceptibility in Brazilians.NOD2基因和CCDC122-LACC1基因与巴西人的麻风易感性相关。
Hum Genet. 2014 Dec;133(12):1525-32. doi: 10.1007/s00439-014-1502-9. Epub 2014 Nov 4.
4
Caries: review of human genetics research.龋齿：人类遗传学研究综述
Caries Res. 2014;48(5):491-506. doi: 10.1159/000358333. Epub 2014 May 21.
5
Role of TRAV locus in low caries experience.TRAV 基因座在低龋经验中的作用。
Hum Genet. 2013 Sep;132(9):1015-25. doi: 10.1007/s00439-013-1313-4. Epub 2013 May 9.
6
Fine-mapping of 5q12.1-13.3 unveils new genetic contributors to caries.5q12.1-13.3 精细定位揭示了龋齿的新遗传贡献因素。
Caries Res. 2013;47(4):273-83. doi: 10.1159/000346278. Epub 2013 Jan 30.
7
Heritable patterns of tooth decay in the permanent dentition: principal components and factor analyses.恒牙龋病的遗传模式：主成分和因子分析。
BMC Oral Health. 2012 Mar 9;12:7. doi: 10.1186/1472-6831-12-7.
8
Analysis of polymorphisms in the lactotransferrin gene promoter and dental caries.乳铁蛋白基因启动子多态性与龋齿的分析
Int J Dent. 2011;2011:571726. doi: 10.1155/2011/571726. Epub 2011 Dec 8.
本文引用的文献
1
A critical review: an overview of genetic influence on dental caries.一篇综述：遗传对龋齿的影响概述。
Oral Dis. 2010 Oct;16(7):613-23. doi: 10.1111/j.1601-0825.2010.01675.x.
2
Sex differences in dental caries experience: clinical evidence, complex etiology.性别差异与龋齿发病情况：临床证据，复杂病因。
Clin Oral Investig. 2011 Oct;15(5):649-56. doi: 10.1007/s00784-010-0445-3. Epub 2010 Jul 21.
3
A major gene controls leprosy susceptibility in a hyperendemic isolated population from north of Brazil.一个主要基因控制了巴西北部高度流行的隔离人群中的麻风易感性。
J Infect Dis. 2010 May 15;201(10):1598-605. doi: 10.1086/652007.
4
The antimicrobial peptide DEFB1 is associated with caries.抗菌肽 DEFB1 与龋齿有关。
J Dent Res. 2010 Jun;89(6):631-6. doi: 10.1177/0022034510364491. Epub 2010 Apr 6.
5
Enamel formation genes are associated with high caries experience in Turkish children.牙釉质形成基因与土耳其儿童的高龋齿发生率相关。
Caries Res. 2008;42(5):394-400. doi: 10.1159/000154785. Epub 2008 Sep 10.
6
Genome-wide scan finds suggestive caries loci.全基因组扫描发现提示性龋齿位点。
J Dent Res. 2008 May;87(5):435-9. doi: 10.1177/154405910808700506.
7
Possible association of amelogenin to high caries experience in a Guatemalan-Mayan population.牙釉蛋白与危地马拉玛雅人群中高龋齿发生率之间可能存在的关联。
Caries Res. 2008;42(1):8-13. doi: 10.1159/000111744. Epub 2007 Nov 27.
8
Risk factors and risk indicators associated with high caries experience in Swedish 19-year-olds.瑞典19岁人群中与高龋齿经历相关的风险因素和风险指标。
Acta Odontol Scand. 2006 Oct;64(5):267-73. doi: 10.1080/00016350600613534.
9
Caries Risk: Individual and Population Perspectives. Proceedings of a Symposium at the 81st Annual Meeting of the International Association for Dental Research (IADR). Göteborg, Sweden, 28 June 2003.
Community Dent Oral Epidemiol. 2005 Aug;33(4):239-279.
10
The continuum of dental caries--evidence for a dynamic disease process.龋齿的连续过程——动态疾病过程的证据。
J Dent Res. 2004;83 Spec No C:C39-42. doi: 10.1177/154405910408301s08.
Zotero 插件