HLA-A2 限制性丙型肝炎病毒特异性 CD8+ T 细胞反应的免疫优势与幼稚前体细胞频率有关。
Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive-precursor frequency.
机构信息
University Hospital Freiburg, Department of Medicine II, Hugstetter Str. 55, 79106 Freiburg, Germany.
出版信息
J Virol. 2011 May;85(10):5232-6. doi: 10.1128/JVI.00093-11. Epub 2011 Mar 2.
Abstract
The impact of naïve-precursor frequency on human virus-specific CD8(+) T cell immunodominance is not well understood. Using a recently developed major histocompatibility complex (MHC) class I tetramer enrichment protocol, we found a conserved hierarchy and a >10-fold difference in naïve-precursor frequencies across three HLA-A2-restricted hepatitis C virus (HCV)-specific epitopes. Importantly, the NS3(1406) epitope with the highest naïve-precursor frequency in healthy donors was also the most frequently targeted epitope in a large cohort of chronically HCV-infected patients, both ex vivo and after in vitro stimulation. These results indicate for the first time that immunodominance in a human viral infection is linked to naïve-precursor frequency.
摘要
关于初始前体细胞频率对人类病毒特异性 CD8(+) T 细胞免疫优势的影响还不是很清楚。我们使用最近开发的主要组织相容性复合体 (MHC) Ⅰ类四聚体富集方案，发现三个 HLA-A2 限制的丙型肝炎病毒 (HCV) 特异性表位中存在一个保守的等级结构和 10 倍以上的初始前体细胞频率差异。重要的是，在健康供体中具有最高初始前体细胞频率的 NS3(1406)表位也是在大量慢性 HCV 感染患者中的最常靶向表位，无论是在体外还是在体外刺激后。这些结果首次表明，人类病毒感染中的免疫优势与初始前体细胞频率有关。
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本文引用的文献
1
Adaptive immunity to the hepatitis C virus.对丙型肝炎病毒的适应性免疫。
Adv Virus Res. 2010;78:43-86. doi: 10.1016/B978-0-12-385032-4.00002-1.
2
Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation.PD-1、2B4、CD160 和 KLRG1 在耗竭的 HCV 特异性 CD8+ T 细胞上的共表达与抗原识别和 T 细胞分化有关。
PLoS Pathog. 2010 Jun 10;6(6):e1000947. doi: 10.1371/journal.ppat.1000947.
3
Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion.在小鼠中，初级 CTL 反应的强度取决于初始 T 细胞的募集程度和随后的克隆扩增。
J Clin Invest. 2010 Jun;120(6):1885-94. doi: 10.1172/JCI41538. Epub 2010 May 3.
4
Enumeration of human antigen-specific naive CD8+ T cells reveals conserved precursor frequencies.枚举人类抗原特异性幼稚 CD8+ T 细胞揭示了保守的前体频率。
Blood. 2010 May 6;115(18):3718-25. doi: 10.1182/blood-2009-10-251124. Epub 2010 Mar 3.
5
Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution.丙型肝炎病毒 (HCV) 序列变异诱导类似于自发缓解的 HCV 特异性 T 细胞表型。
J Virol. 2010 Feb;84(3):1656-63. doi: 10.1128/JVI.01499-09. Epub 2009 Nov 11.
6
Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance.初始前体频率和MHC结合而非表位多样性程度塑造了CD8+T细胞免疫显性。
J Immunol. 2008 Aug 1;181(3):2124-33. doi: 10.4049/jimmunol.181.3.2124.
7
Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection.内源性初始CD8 + T细胞前体频率调节对感染的初次和记忆反应。
Immunity. 2008 Jun;28(6):859-69. doi: 10.1016/j.immuni.2008.04.010. Epub 2008 May 22.
8
Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection.慢性丙型肝炎病毒感染时肝内病毒特异性CD8 + T细胞功能衰竭的病毒学和免疫学决定因素。
Hepatology. 2008 Jun;47(6):1824-36. doi: 10.1002/hep.22242.
9
Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus.确定丙型肝炎病毒感染个体中流感病毒特异性CD8 + T细胞交叉反应的方向性和质量。
J Clin Invest. 2008 Mar;118(3):1143-53. doi: 10.1172/JCI33082.
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J Viral Hepat. 2008 Mar;15(3):219-28. doi: 10.1111/j.1365-2893.2007.00934.x. Epub 2008 Jan 10.
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