Nissen S E, Grines C L, Gurley J C, Sublett K, Haynie D, Diaz C, Booth D C, DeMaria A N
Division of Cardiovascular Medicine, University of Kentucky, College of Medicine, Lexington.
Circulation. 1990 Feb;81(2):660-6. doi: 10.1161/01.cir.81.2.660.
Tomographic imaging techniques such as ultrasound can provide important information in the evaluation of vascular anatomy. Recent technical advances have permitted fabrication of a small (1.83 mm), phased-array, intravascular ultrasonic imaging catheter capable of continuous real-time, cross-sectional imaging of blood vessels. We used this imaging catheter to compare intraluminal ultrasound with cineangiography in the measurement of vascular dimensions in animals and to assess the intraobserver and interobserver variability of the technique. Segmental deformation of vessel anatomy was produced by stenoses created with a tissue ligature or by balloon dilation. The mean value for measurements of vessel diameter was 5.6 mm by cineangiography and 5.7 mm by intravascular ultrasound. The correlation between cineangiography and ultrasound was close (r = 0.98). Mean cross-sectional area by angiography was 28.8 mm2 and 29.6 mm2 (r = 0.96) by ultrasound. Percent diameter reduction produced by the stenoses averaged 48.4% by cineangiography and 40.1% by ultrasound, and the two methods correlated closely (r = 0.89). Correlation between cineangiography and ultrasound for vessel diameter and area before balloon dilation was closer (r = 0.92 and 0.88) than after balloon dilation (r = 0.86 and 0.81). This difference reflected an increase in measured vessel eccentricity following balloon dilation. These data demonstrate that intravascular ultrasound is an accurate and reproducible method for measurement of vascular diameter and cross-sectional area in vivo. Intravascular ultrasound is capable of accurately identifying and quantifying segmental deformation of vascular dimensions produced by either stenoses or balloon dilation.
断层成像技术，如超声，在评估血管解剖结构时可提供重要信息。最近的技术进步已使制造出一种小型（1.83毫米）相控阵血管内超声成像导管成为可能，该导管能够对血管进行连续实时的横截面成像。我们使用这种成像导管在动物体内比较腔内超声与血管造影术对血管尺寸的测量，并评估该技术在观察者内和观察者间的变异性。通过组织结扎或球囊扩张造成狭窄，从而产生血管解剖结构的节段性变形。血管造影术测量的血管直径平均值为5.6毫米，血管内超声测量值为5.7毫米。血管造影术与超声之间的相关性密切（r = 0.98）。血管造影术测得的平均横截面积为28.8平方毫米，超声测量值为29.6平方毫米（r = 0.96）。狭窄造成的直径缩小百分比，血管造影术平均为48.4%，超声为40.1%，两种方法相关性密切（r = 0.89）。球囊扩张前血管造影术与超声在血管直径和面积方面的相关性（r = 0.92和0.88）比扩张后更紧密（r = 0.86和0.81）。这种差异反映出球囊扩张后测得的血管偏心度增加。这些数据表明，血管内超声是一种在体内测量血管直径和横截面积的准确且可重复的方法。血管内超声能够准确识别和量化由狭窄或球囊扩张导致的血管尺寸节段性变形。
