Helmholtz Centre for Infection Research, Work Group Microbial Drugs, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
J Nat Prod. 2011 Apr 25;74(4):603-8. doi: 10.1021/np100625a. Epub 2011 Apr 1.
Marinoquinoline A (1) was isolated from the gliding bacterium Ohtaekwangia kribbensis together with the novel marinoquinolines B-F (2-6). Their structures were elucidated from NMR and HRESIMS data. The pyrroloquinolines showed weak antibacterial and antifungal activities and moderate cytotoxicity against four growing mammalian cell lines with IC(50) values ranging from 0.3 to 8.0 μg/mL. In a screening against tropical parasites marinoquinolines A-F (1-6) showed activity against Plasmodium falciparum K1 with IC(50) values between 1.7 and 15 μM.
马里诺喹啉 A（1）与新型马里诺喹啉 B-F（2-6）一起从滑行细菌 Ohtaekwangia kribbensis 中分离得到。它们的结构是根据 NMR 和 HRESIMS 数据阐明的。吡咯并喹啉类化合物表现出较弱的抗菌和抗真菌活性，对四种生长中的哺乳动物细胞系具有中等的细胞毒性，IC50值范围为 0.3 至 8.0 μg/mL。在对热带寄生虫的筛选中，马里诺喹啉 A-F（1-6）对疟原虫 K1 表现出活性，IC50值在 1.7 至 15 μM 之间。
