Department of Ophthalmology, University Hospital Basel, Basel, Switzerland.
Invest Ophthalmol Vis Sci. 2011 Jun 17;52(7):4345-9. doi: 10.1167/iovs.10-6972.
To evaluate the potential of brilliant blue G (BBG) and indocyanine green (ICG) for intraoperative staining of the internal limiting membrane (ILM) with respect to perceivable contrast.
In a retrospective clinical case series the authors analyzed 26 consecutive chromovitrectomy interventions in 26 patients with macular holes, epiretinal fibrosis, vitreoretinal traction syndromes, or persistent macular edema. Fourteen subjects underwent ICG and 12 subjects, BBG chromovitrectomy. The main outcome measure was the difference in chromaticity between the stained ILM and the unstained underlying retina, measured by means of a novel objective and quantitative video-based analysis method to describe color contrast strengths as they are perceived by the human eye.
Objective chromaticity measurements of the intraoperative videos of all 26 interventions showed a significantly inferior contrast for BBG compared with that of ICG (BBG = 6.1, ICG = 14.9; P = 3.885 × 10⁻¹⁵).
As an adjunct to chromovitrectomy to stain the ILM, BBG yields a significantly less well discernible contrast to the human eye than that of ICG under the premises of this study.
评估亮蓝 G（BBG）和吲哚菁绿（ICG）在术中对内界膜（ILM）进行染色的潜在能力，以评估其可感知的对比度。
本回顾性临床病例系列研究分析了 26 例连续接受黄斑裂孔、视网膜前膜纤维化、玻璃体视网膜牵引综合征或持续性黄斑水肿的患者共 26 例的经 chromovitrectomy 干预的病例。其中 14 例接受 ICG 治疗，12 例接受 BBG 染色 chromovitrectomy 治疗。主要观察指标为染色的 ILM 和未染色的视网膜下组织之间的色度差，通过一种新的客观和定量视频分析方法进行测量，以描述人眼感知到的颜色对比度强度。
对所有 26 例干预措施的术中视频的客观色度测量显示，与 ICG 相比，BBG 的对比度明显较差（BBG=6.1，ICG=14.9；P=3.885×10⁻¹⁵）。
在本研究的前提下，作为 chromovitrectomy 的辅助手段，BBG 对内界膜进行染色时，与 ICG 相比，人眼可明显识别的对比度明显较差。
