Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Cell Biochem Funct. 2011 Apr;29(3):215-26. doi: 10.1002/cbf.1739. Epub 2011 Mar 4.
Integrative physiology studies have shown that immune system and central nervous system interplay very closely towards behavioural modulation. Since the 70-kDa heat shock proteins (HSP70s), whose heavy expression during exercise is well documented in the skeletal muscle and other tissues, is also extremely well conserved in nature during all evolutionary periods of species, it is conceivable that HSP70s might participate of physiologic responses such as fatigue induced by some types of physical exercise. In this way, increased circulating levels of extracellular HSP70 (eHSP70) could be envisaged as an immunomodulatory mechanism induced by exercise, besides other chemical messengers (e.g. cytokines) released during an exercise effort, that are able to binding a number of receptors in neural cells. Studies from this laboratory led us to believe that increased levels of eHSP70 in the plasma during exercise and the huge release of eHSP70 from lymphocytes during high-load exercise bouts may participate in the fatigue sensation, also acting as a danger signal from the immune system.
整合生理学研究表明，免疫系统和中枢神经系统在行为调节方面相互作用非常密切。由于 70kDa 热休克蛋白（HSP70s）在运动过程中的大量表达在骨骼肌和其他组织中已有充分的记录，而且在物种的所有进化阶段中在自然界中也得到了极好的保存，因此可以想象 HSP70s 可能参与了生理反应，例如某些类型的体育锻炼引起的疲劳。这样，细胞外 HSP70（eHSP70）的循环水平升高可以被视为运动诱导的免疫调节机制，除了在运动过程中释放的其他化学信使（例如细胞因子）之外，这些信使能够与神经细胞中的许多受体结合。本实验室的研究使我们相信，运动过程中血浆中 eHSP70 水平升高，以及高强度运动时淋巴细胞中 eHSP70 的大量释放可能参与了疲劳感，也作为来自免疫系统的危险信号。
