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1
Phenotypic changes in a CD4+ lymphocyte subset correlate with a conversion from suppressor to helper inducer function.CD4+淋巴细胞亚群的表型变化与从抑制功能向辅助诱导功能的转变相关。
Immunology. 1990 Jan;69(1):65-70.
2
Functional heterogeneity of CD4+ T lymphocytes: two subpopulations with counteracting immunoregulatory functions identified with the monoclonal antibodies WR16 and WR19.CD4+ T淋巴细胞的功能异质性：用单克隆抗体WR16和WR19鉴定出具有相互拮抗免疫调节功能的两个亚群。
Immunology. 1987 Jun;61(2):159-65.
3
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4
An immunohistological study of CD4+ lymphocyte subsets within inflammatory lesions with special reference to rheumatoid arthritis and inflammatory bowel disease.关于类风湿性关节炎和炎症性肠病，对炎症性病变内CD4 +淋巴细胞亚群的免疫组织学研究。
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Eur J Immunol. 1988 May;18(5):811-6. doi: 10.1002/eji.1830180523.
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Regulation of immunoglobulin synthesis by human T cell subsets as defined by anti-D44 monoclonal antibody within the CD4+ and CD8+ subpopulations.通过抗 D44 单克隆抗体在 CD4 + 和 CD8 + 亚群中定义的人 T 细胞亚群对免疫球蛋白合成的调节。
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Human epidermal cells from ultraviolet light-exposed skin preferentially activate autoreactive CD4+2H4+ suppressor-inducer lymphocytes and CD8+ suppressor/cytotoxic lymphocytes.来自紫外线照射皮肤的人表皮细胞优先激活自身反应性CD4 + 2H4 +抑制诱导淋巴细胞和CD8 +抑制/细胞毒性淋巴细胞。
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引用本文的文献

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An investigation of T-cell subset phenotype and function in the rheumatoid synovium using in situ hybridization for IL-2 mRNA.利用白细胞介素-2信使核糖核酸原位杂交技术对类风湿性滑膜炎中T细胞亚群的表型和功能进行研究。
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本文引用的文献

1
The isolation and characterization of the human helper inducer T cell subset.人类辅助诱导性T细胞亚群的分离与鉴定。
J Immunol. 1985 Jun;134(6):3762-9.
2
Functional characterization of human T lymphocyte subsets distinguished by monoclonal anti-leu-8.用单克隆抗Leu-8区分的人T淋巴细胞亚群的功能特性
J Immunol. 1985 May;134(5):2995-3002.
3
The isolation and characterization of the human suppressor inducer T cell subset.人类抑制诱导性T细胞亚群的分离与鉴定
J Immunol. 1985 Mar;134(3):1508-15.
4
Subpopulations of T lymphocytes.
Immunol Lett. 1987 Apr;14(4):269-70. doi: 10.1016/0165-2478(87)90002-2.
5
Stop and go in the thymus.胸腺中的停止与继续。
Immunol Today. 1988 Dec;9(12):377-80. doi: 10.1016/0167-5699(88)91238-8.
6
An immunohistological study of CD4+ lymphocyte subsets within inflammatory lesions with special reference to rheumatoid arthritis and inflammatory bowel disease.关于类风湿性关节炎和炎症性肠病，对炎症性病变内CD4 +淋巴细胞亚群的免疫组织学研究。
Immunology. 1988 Nov;65(3):457-63.
7
Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.CD45R缺失和UCHL1反应性增加是预刺激T细胞的一个特征。
J Immunol. 1988 Apr 1;140(7):2171-8.
8
Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event.CD45R（Lp220）的缺失代表胸腺后T细胞分化事件。
J Immunol. 1988 Mar 1;140(5):1435-41.
9
Functional heterogeneity of CD4+ T lymphocytes: two subpopulations with counteracting immunoregulatory functions identified with the monoclonal antibodies WR16 and WR19.CD4+ T淋巴细胞的功能异质性：用单克隆抗体WR16和WR19鉴定出具有相互拮抗免疫调节功能的两个亚群。
Immunology. 1987 Jun;61(2):159-65.
10
Induction of CD4 suppressor T cells with anti-Leu-8 antibody.用抗Leu-8抗体诱导CD4抑制性T细胞。
J Immunol. 1987 Jul 1;139(1):49-54.

CD4+淋巴细胞亚群的表型变化与从抑制功能向辅助诱导功能的转变相关。

Phenotypic changes in a CD4+ lymphocyte subset correlate with a conversion from suppressor to helper inducer function.

作者信息

Nesbitt A M, Jones D B, Moore K

机构信息

University Department of Pathology, Southampton General Hospital, U.K.

出版信息

Immunology. 1990 Jan;69(1):65-70.

PMID:2138125
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1385721/
Abstract

The monoclonal antibodies WR16 (CD45RA) and WR19 were used to isolate two reciprocal subsets of CD4 lymphocytes by negative selection. The CD4+/WR16-/WR19+ subset exhibited helper-inducer activity in a pokeweed mitogen (PWM)-driven Ig secretion assay, whereas the CD4+/WR16+/WR19- subset showed suppressor activity. When the CD4+/WR16+/WR19- subset was cultured in phytohaemagglutinin (PHA) or purified protein derivative (PPD) there was increased expression of the antigen binding WR19 but the cells remained WR16 negative. Cultures of CD4+/WR16+/WR19- lymphocytes with PHA or PPD induced a phenotypic change that resulted in a population which was CD4+/WR16-/WR19+. Investigation of the functional activity of the CD4+/WR16+/WR19- subset, before and after activation and phenotypic change to WR16-/WR19+, indicated that the change in phenotype correlated with a functional conversion from suppressor to helper-inducer activity. These results suggest that the CD4+/WR16+/WR19- suppressor subset comprises cells that differentiate to WR16-/WR19+ helper-inducer cells after exposure to antigen or mitogen.

摘要

单克隆抗体WR16（CD45RA）和WR19用于通过阴性选择分离CD4淋巴细胞的两个相互对应的亚群。在商陆有丝分裂原（PWM）驱动的Ig分泌试验中，CD4+/WR16-/WR19+亚群表现出辅助诱导活性，而CD4+/WR16+/WR19-亚群则显示出抑制活性。当CD4+/WR16+/WR19-亚群在植物血凝素（PHA）或纯化蛋白衍生物（PPD）中培养时，抗原结合性WR19的表达增加，但细胞仍为WR16阴性。用PHA或PPD培养CD4+/WR16+/WR19-淋巴细胞会诱导表型变化，导致产生一个CD4+/WR16-/WR19+的群体。对CD4+/WR16+/WR19-亚群在激活并向WR16-/WR19+表型变化之前和之后的功能活性进行研究，结果表明表型变化与从抑制活性向辅助诱导活性的功能转变相关。这些结果表明，CD4+/WR16+/WR19-抑制亚群包含在接触抗原或有丝分裂原后分化为WR16-/WR19+辅助诱导细胞的细胞。