白内障与老年人白细胞端粒长度的关联：定义新的衰老标志物。
The association of cataract with leukocyte telomere length in older adults: defining a new marker of aging.
机构信息
Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pennsylvania, USA.
出版信息
J Gerontol A Biol Sci Med Sci. 2011 Jun;66(6):639-45. doi: 10.1093/gerona/glr034. Epub 2011 Mar 7.
Abstract
Lens transparency, or the magnitude of cataract severity, is a potential in vivo marker of aging distinguishable from diagnosed cataract. To explore lens transparency as a marker of aging, we determined its association with leukocyte telomere length (LTL) measured with quantitative polymerase chain reaction. Cataract severity was directly measured in 259 participants, and prevalent cataract and incident cataract surgery were ascertained in 2,750 participants of the Health, Aging, and Body Composition Study. LTL was unassociated with clinical cataract outcomes. Six of 259 had successfully aged lenses and a mean LTL of 5,700 bp, whereas 253/259 with poorly aged lenses had a mean LTL of 4,770 bp. Participants with a 1,000 bp greater mean LTL had nearly half the odds of any cataract (odds ratio = 0.47, 95% confidence interval 0.22-1.02) after adjustment. Lens transparency might be associated with longer LTL in community-dwelling older adults and should be investigated further as a possible biomarker of aging.
摘要
晶状体透明度，或白内障严重程度的大小，是一种潜在的体内衰老标志物，与已诊断的白内障不同。为了探索晶状体透明度作为衰老的标志物，我们确定了其与使用定量聚合酶链反应测量的白细胞端粒长度（LTL）的关联。在 259 名参与者中直接测量白内障严重程度，并在健康、衰老和身体成分研究的 2750 名参与者中确定了现患白内障和白内障手术的发生率。LTL 与临床白内障结果无关。在 259 名成功老化的晶状体中，有 6 名的 LTL 平均值为 5700 个碱基对，而在 253/259 个晶状体老化不良的患者中，LTL 平均值为 4770 个碱基对。经调整后，LTL 平均值每增加 1000 个碱基对，任何白内障的可能性就会降低近一半（比值比=0.47，95%置信区间 0.22-1.02）。在社区居住的老年人中，晶状体透明度可能与较长的 LTL 有关，应进一步研究其作为衰老的生物标志物的可能性。
相似文献
1
The association of cataract with leukocyte telomere length in older adults: defining a new marker of aging.白内障与老年人白细胞端粒长度的关联：定义新的衰老标志物。
J Gerontol A Biol Sci Med Sci. 2011 Jun;66(6):639-45. doi: 10.1093/gerona/glr034. Epub 2011 Mar 7.
2
Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study.累积性炎症负荷与健康、衰老和身体成分研究中的白细胞端粒长度缩短有关。
PLoS One. 2011;6(5):e19687. doi: 10.1371/journal.pone.0019687. Epub 2011 May 13.
3
Leukocyte telomere length in multiple sclerosis: relationship between disability severity and pregnancy history.多发性硬化症中的白细胞端粒长度：残疾严重程度与妊娠史的关系。
Mult Scler Relat Disord. 2024 Jun;86:105607. doi: 10.1016/j.msard.2024.105607. Epub 2024 Apr 10.
4
U-Shaped Relationship of Leukocyte Telomere Length With All-Cause and Cancer-Related Mortality in Older Men.老年男性白细胞端粒长度与全因死亡率和癌症相关死亡率的U型关系
J Gerontol A Biol Sci Med Sci. 2021 Jan 1;76(1):164-171. doi: 10.1093/gerona/glaa190.
5
Smoking habits and leukocyte telomere length dynamics among older adults: Results from the ESTHER cohort.老年人的吸烟习惯与白细胞端粒长度动态变化：ESTHER队列研究结果
Exp Gerontol. 2015 Oct;70:18-25. doi: 10.1016/j.exger.2015.07.002. Epub 2015 Aug 6.
6
Association between leukocyte telomere length and bone mineral density in women 25-93 years of age.25至93岁女性白细胞端粒长度与骨密度的关联
Exp Gerontol. 2015 Jun;66:25-31. doi: 10.1016/j.exger.2015.04.004. Epub 2015 Apr 11.
7
Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm.后代的白细胞端粒长度、父亲年龄与精子中的端粒延长
PLoS Genet. 2008 Feb;4(2):e37. doi: 10.1371/journal.pgen.0040037.
8
Leukocyte Telomere Length and All-Cause, Cardiovascular Disease, and Cancer Mortality: Results From Individual-Participant-Data Meta-Analysis of 2 Large Prospective Cohort Studies.白细胞端粒长度与全因、心血管疾病及癌症死亡率：两项大型前瞻性队列研究的个体参与者数据荟萃分析结果
Am J Epidemiol. 2017 Jun 15;185(12):1317-1326. doi: 10.1093/aje/kww210.
9
Association between short leukocyte telomere length and HIV infection in a cohort study: No evidence of a relationship with antiretroviral therapy.短白细胞端粒长度与 HIV 感染的队列研究相关性：无证据表明与抗逆转录病毒治疗有关。
Clin Infect Dis. 2014 May;58(9):1322-32. doi: 10.1093/cid/ciu051. Epub 2014 Jan 22.
10
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women.较高的血清维生素D浓度与女性较长的白细胞端粒长度相关。
Am J Clin Nutr. 2007 Nov;86(5):1420-5. doi: 10.1093/ajcn/86.5.1420.
引用本文的文献
1
Association between leukocyte telomere length and incident glaucoma: A prospective UK biobank study.白细胞端粒长度与青光眼发病之间的关联：一项英国生物银行前瞻性研究。
Eye (Lond). 2025 May 7. doi: 10.1038/s41433-025-03838-7.
2
Leukocytes telomere length as a biomarker of adverse drug reactions induced by Osimertinib in advanced non-small cell lung cancer.白细胞端粒长度作为奥希替尼诱导晚期非小细胞肺癌不良药物反应的生物标志物。
Sci Rep. 2024 Nov 3;14(1):26543. doi: 10.1038/s41598-024-77935-0.
3
Telomere length and socioeconomic status at neighborhood and individual levels among 80,000 adults in the Genetic Epidemiology Research on Adult Health and Aging cohort.在“成人健康与衰老基因流行病学研究”队列中的80000名成年人中，邻里和个体层面的端粒长度与社会经济地位
Environ Epidemiol. 2019 May 1;3(3):e049. doi: 10.1097/EE9.0000000000000049. eCollection 2019 Jun.
4
Ocular findings in metabolic syndrome: a review.代谢综合征的眼部表现：综述
Porto Biomed J. 2020 Dec 3;5(6):e104. doi: 10.1097/j.pbj.0000000000000104. eCollection 2020 Nov-Dec.
5
Comparing the Role of the p53 Gene and Telomerase Enzyme in 'Accelerated Aging Due to Cancer': A Literature Review.比较p53基因和端粒酶在“癌症导致的加速衰老”中的作用：文献综述
Cureus. 2020 Oct 4;12(10):e10794. doi: 10.7759/cureus.10794.
6
Metformin Prevents H₂O₂-Induced Senescence in Human Lens Epithelial B3 Cells.二甲双胍可预防人晶状体上皮细胞 B3 氧化应激诱导的衰老。
Med Sci Monit Basic Res. 2020 Apr 27;26:e923391. doi: 10.12659/MSMBR.923391.
7
The impact of oxidative DNA damage and stress on telomere homeostasis.氧化 DNA 损伤和应激对端粒稳态的影响。
Mech Ageing Dev. 2019 Jan;177:37-45. doi: 10.1016/j.mad.2018.03.013. Epub 2018 Mar 28.
8
Expressions of Senescence-Associated β-Galactosidase and Senescence Marker Protein-30 are Associated with Lens Epithelial Cell Apoptosis.衰老相关β-半乳糖苷酶和衰老标记蛋白30的表达与晶状体上皮细胞凋亡相关。
Med Sci Monit. 2015 Nov 30;21:3728-35. doi: 10.12659/msm.895596.
9
Assessment of candidate ocular biomarkers of ageing in a South African adult population: relationship with chronological age and systemic biomarkers.评估南非成年人候选眼龄生物标志物：与实际年龄和系统生物标志物的关系。
Mech Ageing Dev. 2013 Jul-Aug;134(7-8):338-45. doi: 10.1016/j.mad.2013.05.002. Epub 2013 May 20.
10
Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither?流行病学中的端粒长度：衰老、年龄相关疾病、两者皆有关联或两者皆无关联的生物标志物？
Epidemiol Rev. 2013;35(1):112-31. doi: 10.1093/epirev/mxs008. Epub 2013 Jan 9.
本文引用的文献
1
Is telomere length a biomarker of aging? A review.端粒长度是衰老的生物标志物吗？一篇综述。
J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):202-13. doi: 10.1093/gerona/glq180. Epub 2010 Oct 28.
2
Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study.一项基于人群的队列研究：端粒长度、特定死因与健康、衰老和身体成分中的健康生活年限之间的关联。
J Gerontol A Biol Sci Med Sci. 2009 Aug;64(8):860-4. doi: 10.1093/gerona/glp061. Epub 2009 May 12.
3
Insulin-like growth factors and leukocyte telomere length: the cardiovascular health study.胰岛素样生长因子与白细胞端粒长度：心血管健康研究
J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1103-6. doi: 10.1093/gerona/glp036. Epub 2009 Apr 6.
4
Genetics of crystallins: cataract and beyond.晶状体蛋白的遗传学：白内障及其他相关问题
Exp Eye Res. 2009 Feb;88(2):173-89. doi: 10.1016/j.exer.2008.10.011. Epub 2008 Nov 1.
5
Oxidative stress, lens gap junctions, and cataracts.氧化应激、晶状体缝隙连接与白内障
Antioxid Redox Signal. 2009 Feb;11(2):339-53. doi: 10.1089/ars.2008.2119.
6
Association of longer telomeres with better health in centenarians.端粒较长与百岁老人更健康之间的关联。
J Gerontol A Biol Sci Med Sci. 2008 Aug;63(8):809-12. doi: 10.1093/gerona/63.8.809.
7
Incidence of age-related cataract over a 15-year interval the Beaver Dam Eye Study.比弗迪尔姆眼科研究中15年间年龄相关性白内障的发病率。
Ophthalmology. 2008 Mar;115(3):477-82. doi: 10.1016/j.ophtha.2007.11.024. Epub 2008 Jan 2.
8
The lens epithelium: focus on the expression and function of the alpha-crystallin chaperones.晶状体上皮细胞：聚焦α-晶状体蛋白伴侣蛋白的表达与功能
Int J Biochem Cell Biol. 2008;40(3):317-23. doi: 10.1016/j.biocel.2007.10.034. Epub 2007 Nov 13.
9
Ten-year incidence of age-related cataract and cataract surgery in an older Australian population. The Blue Mountains Eye Study.澳大利亚老年人群中年龄相关性白内障及白内障手术的十年发病率。蓝山眼研究。
Ophthalmology. 2008 May;115(5):808-814.e1. doi: 10.1016/j.ophtha.2007.07.008. Epub 2007 Sep 27.
10
Effect of glycation on alpha-crystallin structure and chaperone-like function.糖基化对α-晶状体蛋白结构和伴侣样功能的影响。
Biochem J. 2007 Dec 1;408(2):251-8. doi: 10.1042/BJ20070989.
Zotero 插件