J Heyrovský Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Dolejškova 3, 182 23, Prague 8, Czech Republic.
J Breath Res. 2007 Dec;1(2):026001. doi: 10.1088/1752-7155/1/2/026001. Epub 2007 Oct 16.
The concentrations of ammonia, acetone, methanol, ethanol, propanol and hydrogen cyanide have been measured in the exhaled breath of 26 young adults of age 17/18 years, using selected ion flow tube mass spectrometry (SIFT-MS). Thus the concentration distributions have been constructed and are seen to be essentially log normal with median values in parts per billion (ppb), being ammonia, 317; acetone, 363; methanol, 238; ethanol, 104; propanol, 13; hydrogen cyanide (HCN), 8. There is a clear separation in the median breath ethanol levels between those volunteers who had ingested sugary food/drinks (109 ppb) and those who had not (48 ppb). These data are compared with the results of a study of the same breath compounds, excepting HCN, for a similar sized cohort of healthy volunteers within the age range of 20 to 60 years, which shows that the median levels of these compounds are lower in the young adult volunteer cohort. These HCN measurements are the first to be made in the breath of healthy individuals. The potential implications of these combined results for clinical diagnosis are alluded to.
使用选择离子流管质谱（SIFT-MS）测量了 26 名年龄为 17/18 岁的年轻人呼出的氨气、丙酮、甲醇、乙醇、丙醇和氢氰酸的浓度。因此，构建了浓度分布，发现基本上呈对数正态分布，中位数为十亿分之一（ppb），分别为氨气，317；丙酮，363；甲醇，238；乙醇，104；丙醇，13；氢氰酸（HCN），8。在摄入含糖食物/饮料的志愿者（109 ppb）和未摄入的志愿者（48 ppb）之间，呼气乙醇水平的中位数有明显差异。这些数据与对同一组健康志愿者的相同呼气化合物（除 HCN 外）的研究结果进行了比较，这些志愿者的年龄在 20 至 60 岁之间，结果表明这些化合物的中位数水平在年轻成年志愿者队列中较低。这些 HCN 测量值是首次在健康个体的呼吸中进行的。这些综合结果对临床诊断的潜在影响被提及。
