Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Nat Rev Rheumatol. 2011 Apr;7(4):200-1. doi: 10.1038/nrrheum.2011.26. Epub 2011 Mar 8.
OA is not a disease in short supply of phenotypic definitions. Indeed, numerous classification options complicate the design of genetic studies seeking associations within the obscuring array of heterogeneity. New recommendations offer some progress toward clarifying OA definitions, but much-needed guidelines are wanting.
OA 并不是一种缺乏表型定义的疾病。事实上,众多的分类选择使得在混杂的异质性中寻找关联的遗传研究设计变得复杂。新的建议为澄清 OA 定义提供了一些进展,但仍需要急需制定指南。