Child Study Center, New York University Langone Medical Center, New York, NY, USA.
J Clin Child Adolesc Psychol. 2011;40(2):266-80. doi: 10.1080/15374416.2011.546049.
Despite the nosological distinction between bipolar disorder and schizophrenia, there is increasing evidence that these conditions share phenomenological characteristics. To examine the similarities in their patterns of cognitive impairment, we conducted a meta-analysis from 12 studies of Early Onset Schizophrenia (EOS) and 12 studies of Pediatric Bipolar Disorder (PBD). We found that individuals with PBD suffer from cognitive deficits (e.g., verbal learning and memory, processing speed, or executive control) that are milder but similar in nature to those of patients with EOS. Qualitative similarities between the neuropsychological profiles produced by these groups of patients might represent a "continuum of psychosis" or reflect some degree of genetic biological overlap.
尽管双相情感障碍和精神分裂症在分类上有所区别，但越来越多的证据表明，这两种疾病在表现上存在共同特征。为了探究它们在认知障碍模式上的相似性，我们对 12 项早发性精神分裂症（EOS）研究和 12 项儿童双相情感障碍（PBD）研究进行了荟萃分析。我们发现，PBD 患者存在认知缺陷（例如，言语学习和记忆、加工速度或执行控制），其严重程度较轻，但与 EOS 患者的认知缺陷相似。这些患者群体产生的神经心理学特征存在定性相似性，这可能代表一种“精神病连续体”，或者反映出一定程度的遗传生物学重叠。
