测量变应性鼻炎的结局：鼻塞定量测试七项量表（CQ7）西班牙语版的心理计量学特征。

Measuring outcomes in allergic rhinitis: psychometric characteristics of a Spanish version of the congestion quantifier seven-item test (CQ7).

机构信息

Allergy Unit, Pneumology and Allergy Department, Hospital Clínic, Villarroel 170, Barcelona 08036, Spain.

出版信息

Health Qual Life Outcomes. 2011 Mar 10;9:14. doi: 10.1186/1477-7525-9-14.

DOI:10.1186/1477-7525-9-14

PMID:21392375

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3063809/

Abstract

BACKGROUND

No control tools for nasal congestion (NC) are currently available in Spanish. This study aimed to adapt and validate the Congestion Quantifier Seven Item Test (CQ7) for Spain.

METHODS

CQ7 was adapted from English following international guidelines. The instrument was validated in an observational, prospective study in allergic rhinitis patients with NC (N = 166) and a control group without NC (N = 35). Participants completed the CQ7, MOS sleep questionnaire, and a measure of psychological well-being (PGWBI). Clinical data included NC severity rating, acoustic rhinometry, and total symptom score (TSS). Internal consistency was assessed using Cronbach's alpha and test-retest reliability using the intraclass correlation coefficient (ICC). Construct validity was tested by examining correlations with other outcome measures and ability to discriminate between groups classified by NC severity. Sensitivity and specificity were assessed using Area under the Receiver Operating Curve (AUC) and responsiveness over time using effect sizes (ES).

RESULTS

Cronbach's alpha for the CQ7 was 0.92, and the ICC was 0.81, indicating good reliability. CQ7 correlated most strongly with the TSS (r = 0.60, p < 0.01), the PGWBI general health dimension (r = 0.56, p < 0.01), and the MOS Sleep scale 'sleep short of breath' dimension (r = 0.49, p < 0.01). Correlations with acoustic rhinometry were generally low. The instrument discriminated well between NC severity groups (ES 0.33-2.07) and AUC was 0.93, indicating excellent sensitivity and specificity. The measure was responsive to change (ES = 1.1) in patients reporting improvement in NC.

CONCLUSIONS

The Spanish version of the CQ7 is appropriate for detecting, measuring, and monitoring NC in allergic rhinitis patients.

摘要

背景

目前西班牙语中尚无针对鼻塞（NC）的控制工具。本研究旨在对鼻塞量化七项测试（CQ7）进行改编和验证，以适用于西班牙。

方法

根据国际指南，将 CQ7 从英文改编而来。在一项针对伴有 NC 的变应性鼻炎患者（NC 组，N=166）和无 NC 的对照组患者（NC 组，N=35）的观察性、前瞻性研究中对该工具进行了验证。参与者完成了 CQ7、MOS 睡眠问卷和心理幸福感量表（PGWBI）。临床数据包括 NC 严重程度评分、声鼻反射测量和总症状评分（TSS）。使用 Cronbach's alpha 评估内部一致性，使用组内相关系数（ICC）评估测试-再测试可靠性。通过检查与其他结局测量的相关性以及区分按 NC 严重程度分类的组的能力来检验结构有效性。使用受试者工作特征曲线下面积（AUC）评估敏感性和特异性，并使用效应大小（ES）评估随时间的反应性。

结果

CQ7 的 Cronbach's alpha 为 0.92，ICC 为 0.81，表明可靠性良好。CQ7 与 TSS（r=0.60，p<0.01）、PGWBI 一般健康维度（r=0.56，p<0.01）和 MOS 睡眠量表“呼吸短促”维度（r=0.49，p<0.01）相关性最强。与声鼻反射测量的相关性通常较低。该工具能很好地区分 NC 严重程度组（ES 0.33-2.07），AUC 为 0.93，表明敏感性和特异性极佳。该测量方法对报告 NC 改善的患者的变化具有反应性（ES=1.1）。