尼古丁对大鼠正畸牙移动的影响。
Effect of nicotine on orthodontic tooth movement in rats.
机构信息
Assistant professor, Department of Orthodontics and Center of Researches, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Am J Orthod Dentofacial Orthop. 2011 Mar;139(3):e261-5. doi: 10.1016/j.ajodo.2010.08.018.
INTRODUCTION
Although the detrimental health effects of cigarettes are well known, many people, including some orthodontic patients, continue to smoke. Nicotine can affect bone resorption and apposition. Therefore, the aim of this study was to investigate the effect of nicotine on orthodontic tooth movement.
METHODS
Thirty-two adult male Sprague-Dawley rats were randomly divided into 3 experimental groups and 1 control group. With the rats under general anesthesia, 5-mm nickel-titanium closed-coil springs were placed between the maxillary right first molars and first incisors. Injections of nicotine were administered daily for 13 days: group A, 0.5 mg per kilogram; group B, 0.75 mg per kilogram; and group C, 1 mg per kilogram. Group D, the control group, received injections of 0.1 mL of normal saline solution. At the end of the experimental period, the rats were killed, and interproximal tooth movements were measured.
RESULTS
The mean amounts of tooth movement were 0.47 mm in group A, 0.62 mm in group B, 0.78 mm in group C, and 0.21 mm in group D. Statistical analysis with analyis of variance (ANOVA) test showed significant differences between all groups. The most movement occurred in group C, and group D had the least movement.
CONCLUSIONS
Nicotine accelerates orthodontic tooth movement, and this effect is dose-dependent. Nicotine's role in accelerating tooth movement might be related to its effect of accelerating bone resorption.
简介
尽管香烟对健康的有害影响众所周知，但许多人，包括一些正畸患者，仍在继续吸烟。尼古丁会影响骨吸收和骨形成。因此，本研究旨在探讨尼古丁对正畸牙齿移动的影响。
方法
将 32 只成年雄性 Sprague-Dawley 大鼠随机分为 3 个实验组和 1 个对照组。在大鼠全身麻醉下，在右上颌第一磨牙和第一切牙之间放置 5mm 镍钛封闭线圈弹簧。每天对尼古丁进行注射，共 13 天：A 组，0.5mg/kg；B 组，0.75mg/kg；C 组，1mg/kg。C 组，对照组，注射 0.1mL 生理盐水。实验结束时，处死大鼠，测量近中牙齿移动量。
结果
A 组平均牙齿移动量为 0.47mm，B 组为 0.62mm，C 组为 0.78mm，D 组为 0.21mm。方差分析（ANOVA）检验的统计学分析显示，所有组之间均存在显著差异。C 组的移动量最大，D 组的移动量最小。
结论
尼古丁加速正畸牙齿移动，这种作用具有剂量依赖性。尼古丁加速牙齿移动的作用可能与其加速骨吸收的作用有关。
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