Department of Pediatrics, Osaka Medical College, Daigaku-Cho 2-7, Takatsuki, 569-8686, Japan.
Dig Dis Sci. 2011 Aug;56(8):2372-7. doi: 10.1007/s10620-011-1633-y. Epub 2011 Mar 11.
Studies evaluating the correlation between endoscopic disease activity and noninvasive markers are scarce in inflammatory bowel disease (IBD).
The aim of this study is to evaluate the accuracy of the fecal calprotectin (FC) assay as a marker of disease activity of IBD, as determined by an extensive endoscopic scoring system.
Thirty-five children and adolescents with IBD [17 with ulcerative colitis (UC) and 18 with Crohn's disease (CD)] and 28 healthy volunteers were enrolled. FC levels were determined by ELISA. The sum of Matts' score for UC and the simple endoscopic score for Crohn's disease (SES-CD) were used. The ileal lesions were evaluated by ultrasonography.
In UC patients, there was a strong correlation between FC levels and the sum of Matts' score (r=0.838, p<0.01). FC levels were significantly elevated in endoscopically active patients (median 1,562.5 μg/g) as compared to patients in endoscopic remission (median 38.9 μg/g) or healthy controls (median 19.9 μg/g). In CD patients, there was a strong correlation between FC levels and the SES-CD score (r=0.760, p<0.01). The FC levels were significantly higher in endoscopically active patients (median 2,037.5 μg/g) than in endoscopically inactive patients (median 172.5 μg/g) or healthy controls (median 19.9 μg/g), respectively. The FC levels of patients with ileal wall thickening (median 2,225.0 μg/g) were significantly higher than healthy controls (median 19.9 μg/g) and patients lacking ileal wall thickening (median 17.5 μg/g), respectively.
The FC assay is a useful marker for the detection of mucosal inflammation in pediatric IBD patients.
评估内镜疾病活动与非侵入性标志物之间相关性的研究在炎症性肠病（IBD）中较为匮乏。
本研究旨在评估粪便钙卫蛋白（FC）检测作为一种广泛内镜评分系统评估 IBD 疾病活动的标志物的准确性。
共纳入 35 名儿童和青少年 IBD 患者（17 名溃疡性结肠炎（UC）患者和 18 名克罗恩病（CD）患者）和 28 名健康志愿者。采用 ELISA 法测定 FC 水平。采用 Matts 评分总和评估 UC，采用简单克罗恩病内镜评分（SES-CD）评估 CD。通过超声评估回肠病变。
在 UC 患者中，FC 水平与 Matts 评分总和呈强相关性（r=0.838，p<0.01）。与内镜缓解患者（中位数 38.9μg/g）或健康对照者（中位数 19.9μg/g）相比，内镜活动患者（中位数 1562.5μg/g）的 FC 水平显著升高。在 CD 患者中，FC 水平与 SES-CD 评分呈强相关性（r=0.760，p<0.01）。与内镜无活动患者（中位数 172.5μg/g）或健康对照者（中位数 19.9μg/g）相比，内镜活动患者（中位数 2037.5μg/g）的 FC 水平显著升高。存在回肠壁增厚患者（中位数 2225.0μg/g）的 FC 水平显著高于健康对照者（中位数 19.9μg/g）和无回肠壁增厚患者（中位数 17.5μg/g）。
FC 检测是一种用于检测儿科 IBD 患者黏膜炎症的有用标志物。
