果蝇细胞周期蛋白A和B在有丝分裂调控中的作用。
The roles of Drosophila cyclins A and B in mitotic control.
作者信息
Lehner C F, O'Farrell P H
机构信息
Department of Biochemistry and Biophysics, University of California, San Francisco 94143.
出版信息
Cell. 1990 May 4;61(3):535-47. doi: 10.1016/0092-8674(90)90535-m.
Abstract
We have cloned, sequenced, and characterized the expression of a Drosophila cyclin B gene. The independent evolutionary conservation of A- and B-type cyclins implies that they have distinct roles. Indeed, in mutant embryos deficient in cyclin A, cells that accumulate only cyclin B do not enter mitosis. Thus, in vivo, cyclin B is not sufficient for mitosis. Furthermore, we find that the two cyclins are coexpressed in all proliferating cells throughout development. Though lacking a formal demonstration that cyclin B is essential as it is in other organisms, we propose that each of these proteins fulfills a distinct and essential role in the cell cycle.
摘要
我们已经克隆、测序并鉴定了果蝇细胞周期蛋白B基因的表达。A 型和 B 型细胞周期蛋白在进化上的独立保守性表明它们具有不同的作用。事实上，在缺乏细胞周期蛋白 A 的突变胚胎中，仅积累细胞周期蛋白 B 的细胞不会进入有丝分裂。因此，在体内，细胞周期蛋白 B 不足以驱动有丝分裂。此外，我们发现这两种细胞周期蛋白在整个发育过程中的所有增殖细胞中共同表达。虽然缺乏像在其他生物体中那样关于细胞周期蛋白 B 必不可少的正式证明，但我们认为这些蛋白质中的每一种在细胞周期中都发挥着独特且必不可少的作用。
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