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插入序列 ISAba11 参与鲍曼不动杆菌的多粘菌素耐药和脂多糖丢失。

Insertion sequence ISAba11 is involved in colistin resistance and loss of lipopolysaccharide in Acinetobacter baumannii.

机构信息

Department of Microbiology, Monash University, Victoria, Australia.

出版信息

Antimicrob Agents Chemother. 2011 Jun;55(6):3022-4. doi: 10.1128/AAC.01732-10. Epub 2011 Mar 14.

DOI:10.1128/AAC.01732-10
PMID:21402838
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3101452/
Abstract

Infections caused by Acinetobacter baumannii are of increasing concern, largely due to the multidrug resistance of many strains. Here we show that insertion sequence ISAba11 movement can result in inactivation of the A. baumannii lipid A biosynthesis genes lpxA and lpxC, resulting in the complete loss of lipopolysaccharide production and high-level colistin resistance.

摘要

鲍曼不动杆菌引起的感染越来越受到关注，主要是由于许多菌株具有多药耐药性。在这里，我们表明插入序列 ISAba11 的移动可导致鲍曼不动杆菌脂质 A 生物合成基因 lpxA 和 lpxC 的失活，导致脂多糖产生完全丧失和高水平的多粘菌素耐药性。

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本文引用的文献

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A novel insertion sequence, ISAba10, inserted into ISAba1 adjacent to the bla(OXA-23) gene and disrupting the outer membrane protein gene carO in Acinetobacter baumannii.一种新型插入序列 ISAba10，插入到鲍曼不动杆菌 ISAba1 附近的 bla(OXA-23)基因旁，破坏了外膜蛋白基因 carO。
Antimicrob Agents Chemother. 2011 Jan;55(1):361-3. doi: 10.1128/AAC.01672-09. Epub 2010 Oct 11.
2
Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production.鲍曼不动杆菌中的黏菌素耐药性是由脂多糖产生完全丧失介导的。
Antimicrob Agents Chemother. 2010 Dec;54(12):4971-7. doi: 10.1128/AAC.00834-10. Epub 2010 Sep 20.
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DDE transposases: Structural similarity and diversity.DDE 转座酶：结构的相似性和多样性。
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Evolution of AbaR-type genomic resistance islands in multiply antibiotic-resistant Acinetobacter baumannii.多重耐药鲍曼不动杆菌 AbaR 型基因组耐药岛的进化。
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Prevalence and spread of integron-IS26 in imipenem-resistant Acinetobacter baumannii clinical isolates in South Korea.整合子-IS26在韩国耐亚胺培南鲍曼不动杆菌临床分离株中的流行情况及传播
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Overexpression of the naturally occurring blaOXA-51 gene in Acinetobacter baumannii mediated by novel insertion sequence ISAba9.由新型插入序列ISAba9介导的鲍曼不动杆菌中天然存在的blaOXA - 51基因的过表达。
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New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis.通过高密度焦磷酸测序和转座子诱变揭示鲍曼不动杆菌致病机制的新见解。
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