AMRESH SHRIVASTAVA, MD(Psy)., DPM., Consultant Psychiatrist, Silver Mind Hospital. 209. Shivkripa Complex, Gokhale Road. Thane. Mumbai-400 602.
Indian J Psychiatry. 2000 Jan;42(1):52-6.
The study compares the efficacy of risperidone and haloperidol in patients of schizophrenia on various clinical and psychosocial parameters.In the present open, comparative study, in patients suffering from schizophrenia (DSM-IV), 50 patients each were randomly treated with risperidone and haloperidol over a period of 1 year. The clinical improvement was judged on PANSS (Positive and Negative Symptom Scale) and CGIS (Clinical Global Impression Scale). The improvement in psychosocial functioning and other areas was judged using a five point scale (0-4). Though the improvement on PANSS was comparable in both the groups except on the general psychopathology subscale, on CGIS a better improvement profile was observed in risperidone group. In the other psychosocial areas such as social functioning, productivity and education a significantly more number of patients showed improvement in risperidone group as compared to haloperidol group. In significantly less number of patients suicidality and rehospitalization was found in risperidone group as compared to haloperidol group.
本研究比较了利培酮和氟哌啶醇在精神分裂症患者各种临床和社会心理参数上的疗效。在本开放、对照研究中，对患有精神分裂症（DSM-IV）的患者，随机分为利培酮组和氟哌啶醇组，每组 50 例，疗程为 1 年。采用阳性和阴性症状量表（PANSS）和临床总体印象量表（CGIS）评定临床改善情况。采用 5 分制（0-4）评定社会心理功能等其他方面的改善情况。尽管两组在 PANSS 上的改善情况相当，但除一般精神病学亚量表外，利培酮组在 CGIS 上的改善情况更好。在其他社会心理领域，如社会功能、生产力和教育，与氟哌啶醇组相比，利培酮组有更多的患者显示出显著改善。与氟哌啶醇组相比，利培酮组的自杀意念和再住院率明显较少。
