Department of Endocrinology, Odense University Hospital, DK-5000 Odense, Denmark.
Osteoporos Int. 2012 Feb;23(2):521-31. doi: 10.1007/s00198-011-1575-4. Epub 2011 Mar 16.
Risk factors for fractures were assessed in a random sample of 4,696 elderly men followed for 5.4 years. Results highlighted the importance of assessment of falls and dizziness as well as novel risk factors including frequent urination and erectile dysfunction.
Knowledge about risk factors for fracture in men is limited. The aim of this study was to evaluate factors potentially associated with fracture risk in men.
A questionnaire enquiring about potential risk factors for fractures in men was posted to a random sample of 9,314 men aged 60-74 years. A completed questionnaire was returned by 4,696 (50.4%). Follow-up on incident fractures over 5.4 years was performed using public registries.
During the study, 203 individuals experienced a first clinical fracture, of which 85 patients were considered osteoporotic (9 in humerus, 10 vertebral, 32 in the hip and 34 in the forearm). Cox proportional hazard regression models were used to evaluate risk factors for any and osteoporotic fractures. The following variables were found to be associated with increased risk of any fracture in adjusted models family history of a hip fracture (HR; 95%CI: 1.56; 1.05-2.33), falls (2-4/year: 2.10; 1.35-3.27, >4/year: 2.46; 1.12-5.41, both compared to no falls), dizziness (2.36; 1.51-3.71), erectile dysfunction (1.41; 1.06-1.87) and frequent urination (2.06; 1.26-3.39). Similarly, falls (2.36; 1.45-3.86), dizziness (2.83; 1.52-5.25), erectile dysfunction (2.01; 1.30-3.09) and pulmonary illness (1.90; 1.03-3.53) were associated with increased risk of osteoporotic fractures in adjusted models.
These results underline the importance of assessment of dizziness, falls and those with a family history of hip fracture. Frequent urination and erectile dysfunction were independently associated with increased fracture risk. Although the mechanism of association is unknown, these variables are likely to be indicators of frailty or hypogonadism.
在一项针对 4696 名随访 5.4 年的老年男性的随机样本中，评估了骨折的危险因素。结果强调了评估跌倒和头晕的重要性，以及包括频繁排尿和勃起功能障碍在内的新的危险因素。
男性骨折危险因素的知识有限。本研究的目的是评估与男性骨折风险相关的潜在因素。
向年龄在 60-74 岁的 9314 名男性随机样本邮寄了一份询问男性骨折潜在危险因素的问卷。4696 名（50.4%）男性完成了问卷。通过公共登记处对 5.4 年内的新发骨折进行随访。
在研究期间，203 名男性经历了首次临床骨折，其中 85 名被认为是骨质疏松性骨折（9 例肱骨、10 例椎体、32 例髋部和 34 例前臂）。使用 Cox 比例风险回归模型评估任何和骨质疏松性骨折的危险因素。在调整后的模型中，以下变量与任何骨折风险增加相关：家族髋部骨折史（HR；95%CI：1.56；1.05-2.33）、跌倒（每年 2-4 次：2.10；1.35-3.27，每年>4 次：2.46；1.12-5.41，与无跌倒相比）、头晕（2.36；1.51-3.71）、勃起功能障碍（1.41；1.06-1.87）和频繁排尿（2.06；1.26-3.39）。同样，跌倒（2.36；1.45-3.86）、头晕（2.83；1.52-5.25）、勃起功能障碍（2.01；1.30-3.09）和肺部疾病（1.90；1.03-3.53）与调整后的模型中骨质疏松性骨折风险增加相关。
这些结果强调了评估头晕、跌倒和家族髋部骨折史的重要性。频繁排尿和勃起功能障碍与骨折风险增加独立相关。尽管其关联机制尚不清楚，但这些变量可能是脆弱或性腺功能减退的指标。
