Poole A R, Witter J, Roberts N, Piccolo F, Brandt R, Paquin J, Baron M
Joint Diseases Laboratory, Shriners Hospital for Crippled Children, Montreal, Quebec, Canada.
Arthritis Rheum. 1990 Jun;33(6):790-9. doi: 10.1002/art.1780330605.
Single analyses of peripheral blood of rheumatoid arthritis (RA) patients showed a significant reduction in the mean value for keratan sulfate (KS) compared with that in control subjects, but the mean value for orosomucoid (OM) was elevated compared with that in control subjects. Some RA patients displayed highly elevated levels of hyaluronic acid (HA), while others exhibited normal levels. There was a significant inverse correlation between OM and KS content in RA patients, as well as a direct correlation between HA and OM. In longitudinal studies of RA patients, parallel changes in OM and HA and inverse changes between KS and OM or HA were commonly observed. Clinical analyses revealed that there was an inverse correlation between KS and morning stiffness, and direct correlations between the number of tender joints and HA, and between HA or the erythrocyte sedimentation rate and the number of joints with effusions. The reason(s) for the inverse correlation between KS and OM as an index of systemic inflammation remains to be established. Circulating HA represents an index of joint inflammation, for which a marker has not been previously available.
对类风湿性关节炎（RA）患者外周血的单次分析显示，与对照组相比，硫酸角质素（KS）的平均值显著降低，但类粘蛋白（OM）的平均值高于对照组。一些RA患者的透明质酸（HA）水平大幅升高，而另一些患者的水平正常。RA患者中，OM与KS含量之间存在显著负相关，HA与OM之间存在正相关。在对RA患者的纵向研究中，通常观察到OM和HA的平行变化以及KS与OM或HA之间的反向变化。临床分析表明，KS与晨僵之间存在负相关，压痛关节数量与HA之间、HA或红细胞沉降率与积液关节数量之间存在正相关。KS与作为全身炎症指标的OM之间负相关的原因尚待确定。循环中的HA代表关节炎症指标，此前尚无该指标的标志物。
