类风湿关节炎患者血清硫酸角质素水平：与放射学分期呈负相关。
Serum keratan sulfate levels in rheumatoid arthritis: inverse correlation with radiographic staging.
作者信息
Haraoui B, Thonar E J, Martel-Pelletier J, Goulet J R, Raynauld J P, Ouellet M, Pelletier J P
机构信息
Rheumatic Disease Unit, Notre-Dame Hospital Research Center, Montreal, PQ, Canada.
出版信息
J Rheumatol. 1994 May;21(5):813-7.
OBJECTIVE
To correlate the serum levels of keratan sulfate (KS) in patients with rheumatoid arthritis (RA) with different clinical and radiographic variables.
METHODS
Serum KS levels were measured in 85 patients with RA and 41 age matched controls. Patients with RA were classified according to their disease activity, the presence of rheumatoid factor, the medication prescribed, and to the severity of the joint radiographic changes.
RESULTS
Patients with RA had significantly (p < 0.02) higher levels of serum KS compared to the healthy controls. More significantly, there was an inverse correlation of the serum KS levels with the disease activity (p = 0.02) and the severity of the radiographic changes (p = 0.012).
CONCLUSIONS
Serum KS levels appear to correlate with the severity of articular cartilage damage in RA.
目的
将类风湿关节炎（RA）患者血清硫酸角质素（KS）水平与不同临床及影像学变量进行关联分析。
方法
检测85例RA患者及41例年龄匹配的对照者的血清KS水平。RA患者根据疾病活动度、类风湿因子的存在情况、所开药物及关节影像学改变的严重程度进行分类。
结果
与健康对照相比，RA患者血清KS水平显著升高（p < 0.02）。更显著的是，血清KS水平与疾病活动度（p = 0.02）及影像学改变的严重程度（p = 0.012）呈负相关。
结论
血清KS水平似乎与RA关节软骨损伤的严重程度相关。
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