The Intermountain Injury Control Research Center, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
J Am Med Inform Assoc. 2011 May 1;18(3):225-31. doi: 10.1136/jamia.2010.004317. Epub 2011 Mar 21.
To determine the association between the frequencies of pharmaceutical exposures reported to a poison control center (PCC) and those seen in the emergency department (ED).
A statewide population-based retrospective comparison of frequencies of ED pharmaceutical poisonings with frequencies of pharmaceutical exposures reported to a regional PCC. ED poisonings, identified by International Classification of Diseases, Version 9 (ICD-9) codes, were grouped into substance categories. Using a reproducible algorithm facilitated by probabilistic linkage, codes from the PCC classification system were mapped into the same categories. A readily identifiable subset of PCC calls was selected for comparison.
Correlations between frequencies of quarterly exposures by substance categories were calculated using Pearson correlation coefficients and partial correlation coefficients with adjustment for seasonality.
PCC reported exposures correlated with ED poisonings in nine of 10 categories. Partial correlation coefficients (r(p)) indicated strong associations (r(p)>0.8) for three substance categories that underwent large changes in their incidences (opiates, benzodiazepines, and muscle relaxants). Six substance categories were moderately correlated (r(p)>0.6). One category, salicylates, showed no association. Limitations Imperfect overlap between ICD-9 and PCC codes may have led to miscategorization. Substances without changes in exposure frequency have inadequate variability to detect association using this method.
PCC data are able to effectively identify trends in poisonings seen in EDs and may be useful as part of a pharmaceutical poisoning surveillance system. The authors developed an algorithm-driven technique for mapping American Association of Poison Control Centers codes to ICD-9 codes and identified a useful subset of poison control exposures for analysis.
确定向中毒控制中心（PCC）报告的药物暴露频率与急诊科（ED）中观察到的药物暴露频率之间的关联。
一项基于全州的回顾性比较研究，比较 ED 药物中毒的频率与向区域 PCC 报告的药物暴露频率。通过国际疾病分类第 9 版（ICD-9）代码识别 ED 中毒，并将其分为物质类别。使用概率链接提供的可重复算法，将 PCC 分类系统的代码映射到相同的类别中。选择了一个易于识别的 PCC 调用子集进行比较。
使用 Pearson 相关系数和偏相关系数（调整季节性因素）计算按物质类别划分的季度暴露频率之间的相关性。
PCC 报告的暴露与 10 个类别中的 9 个类别中的 ED 中毒相关。偏相关系数（r(p)）表明，在经历了发病率大幅变化的三个物质类别中存在很强的关联（r(p)>0.8），这三个物质类别分别是阿片类药物、苯二氮䓬类药物和肌肉松弛剂。六个物质类别呈中度相关（r(p)>0.6）。一个类别水杨酸酯则没有关联。局限性 ICD-9 和 PCC 代码之间的不完全重叠可能导致分类错误。暴露频率没有变化的物质缺乏足够的可变性，无法使用这种方法检测关联。
PCC 数据能够有效地识别 ED 中观察到的中毒趋势，并且可以作为药物中毒监测系统的一部分有用。作者开发了一种基于算法的技术，用于将美国中毒控制中心代码映射到 ICD-9 代码，并确定了一个有用的 PCC 暴露子集进行分析。
