Department of Orthodontics, São Paulo Methodist University, São Bernardo do Campo, SP, Brazil.
Am J Orthod Dentofacial Orthop. 2011 Apr;139(4 Suppl):e399-404. doi: 10.1016/j.ajodo.2009.06.029.
The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis, and karyorrhexis) in exfoliated buccal mucosa cells from adults after fixed orthodontic therapy.
A total of 23 healthy adults (10 men and 13 women) undergoing orthodontic therapy were included in this setting.
The results pointed out no significant statistically differences (P >0.05) of micronucleated oral mucosa cells. In the same way, orthodontic therapy was not able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis and karyolysis (P >0.05).
In summary, these data indicate that orthodontic therapy may not be a factor that induces chromosomal damage, nor it is able to promote cytotoxicity. Since DNA damage and cellular death are important events during carcinogenic processes, especially in early phases, this study represents a correct evaluation with respect to real health risks induced by orthodontic devices.
本研究旨在评估固定正畸治疗后成年人脱落口腔黏膜细胞中的 DNA 损伤（微核）和细胞死亡（固缩、核溶解和核碎裂）。
本研究共纳入 23 名接受正畸治疗的健康成年人（10 名男性和 13 名女性）。
结果指出，微核口腔黏膜细胞无显著统计学差异（P>0.05）。同样，正畸治疗也不能增加与细胞毒性密切相关的其他核改变，如核碎裂、固缩和核溶解（P>0.05）。
综上所述，这些数据表明正畸治疗可能不是诱导染色体损伤的因素，也不能促进细胞毒性。由于 DNA 损伤和细胞死亡是致癌过程中的重要事件，尤其是在早期阶段，因此本研究代表了对正畸设备引起的实际健康风险的正确评估。
