Grosgogeat Brigitte, Vaicelyte Alina, Gauthier Rémy, Janssen Christine, Le Borgne Marc
Laboratoire des Multimatériaux et des Interfaces, UMR CNRS 5615, Université Claude Bernard Lyon 1, Univ Lyon, 69008 Lyon, France.
Hospices Civils de Lyon, Service d'Odontologie, 69007 Lyon, France.
Materials (Basel). 2022 Aug 23;15(17):5801. doi: 10.3390/ma15175801.
The toxicological risk of Co-Cr dental alloys is actually a sensitive subject with the European regulatory changes, namely regulation (EU) 2017/745 and annex VI to the CLP regulation (EC) 1972/2008. : The objective of this review is to conduct a rigorous analysis of the cytocompatibility of cobalt-chromium (Co-Cr) dental alloys. Considering various parameters such as cytotoxicity, type IV hypersensitivity reaction, sensitization, and irritation, we investigated evidence of toxicity of Co-Cr in human dental applications. : Specific search strategies were performed in three electronic databases, namely , , and , using a main restriction in the search regarding the publication date (1995-2022). : Out of a total of 836 articles, only 21 studies were selected and analyzed according to PRISMA methodology. : Among them, 10 in vitro studies using human samples and 11 in vivo studies on human patients were distinguished. Most of the in vitro studies confirmed that Co-Cr alloys have a good cytocompatibility compared to Ni alloys. Regarding the in vivo studies, it appeared that Co-Cr could rarely cause sensitization, irritation, and allergic reactions. Reactions were mainly observed for people allergic to Co or Cr. Nevertheless, titanium-based materials showed better results. : This study proposes a new state of the art on Co-Cr dental alloys and will thus be very useful for carrying out additional studies. : This review will help practitioners in their daily clinical choice.
随着欧洲法规的变化，即（欧盟）2017/745号法规以及《化学品分类、标签和包装法规》（EC）1972/2008的附件VI，钴铬牙科合金的毒理学风险实际上是一个敏感话题。：本综述的目的是对钴铬（Co-Cr）牙科合金的细胞相容性进行严格分析。考虑到细胞毒性、IV型超敏反应、致敏和刺激等各种参数，我们研究了Co-Cr在人类牙科应用中的毒性证据。：在三个电子数据库，即 、 和 中执行了特定的搜索策略，在搜索中对出版日期设置了主要限制（1995 - 2022年）。：在总共836篇文章中，仅根据PRISMA方法选择并分析了21项研究。：其中，区分出10项使用人类样本的体外研究和11项针对人类患者的体内研究。大多数体外研究证实，与镍合金相比，Co-Cr合金具有良好的细胞相容性。关于体内研究，似乎Co-Cr很少引起致敏、刺激和过敏反应。反应主要在对Co或Cr过敏的人群中观察到。然而，钛基金属材料显示出更好的结果。：本研究提出了关于Co-Cr牙科合金的新的技术水平，因此对于开展更多研究将非常有用。：本综述将有助于从业者在日常临床选择中做出决策。
