Harvard School of Public Health, Department of Nutrition, Boston, MA, USA.
J Acquir Immune Defic Syndr. 2011 Jun 1;57(2):141-5. doi: 10.1097/QAI.0b013e318219a3d1.
Limited data are available on dyslipidemia in HIV-infected patients in resource-limited settings. We performed a cross-sectional analysis in antiretroviral therapy (ART)-naive, non-fasting HIV-infected patients in Tanzania between November 2004 to June 2008. Robust linear regression modeling was performed. Lipid parameters were assessed in 12,513 patients [65% women; median (interquartile range) age, 36 (30-42) years; CD4 count, 143 (51-290) cells/mm]. Low high-density lipoprotein was prevalent in 67% and increased triglyceride in 28%. High triglyceride and low high-density lipoprotein levels were associated with low CD4 counts (P < 0.001). In this ART-naive Tanzanian population, dyslipidemia was highly prevalent and associated with advanced disease. The impact of ART on these changes requires further exploration.
在资源有限的环境下，有关感染 HIV 患者的血脂异常的数据十分有限。我们在 2004 年 11 月至 2008 年 6 月期间对坦桑尼亚未接受过抗逆转录病毒治疗（ART）、非空腹的 HIV 感染患者进行了一项横断面分析。我们进行了稳健线性回归建模。在 12513 名患者中评估了血脂参数[65%为女性；中位数（四分位距）年龄为 36（30-42）岁；CD4 计数为 143（51-290）个/立方毫米]。低高密度脂蛋白血症的患病率为 67%，高甘油三酯血症的患病率为 28%。高甘油三酯和低高密度脂蛋白水平与低 CD4 计数相关（P<0.001）。在这个未接受 ART 的坦桑尼亚人群中，血脂异常的患病率很高，且与疾病的晚期相关。ART 对这些变化的影响需要进一步探讨。
