坦桑尼亚达累斯萨拉姆的 HIV 阳性、初治抗逆转录病毒治疗人群中的血脂异常。
Dyslipidemia in an HIV-positive antiretroviral treatment-naive population in Dar es Salaam, Tanzania.
机构信息
Harvard School of Public Health, Department of Nutrition, Boston, MA, USA.
出版信息
J Acquir Immune Defic Syndr. 2011 Jun 1;57(2):141-5. doi: 10.1097/QAI.0b013e318219a3d1.
Abstract
Limited data are available on dyslipidemia in HIV-infected patients in resource-limited settings. We performed a cross-sectional analysis in antiretroviral therapy (ART)-naive, non-fasting HIV-infected patients in Tanzania between November 2004 to June 2008. Robust linear regression modeling was performed. Lipid parameters were assessed in 12,513 patients [65% women; median (interquartile range) age, 36 (30-42) years; CD4 count, 143 (51-290) cells/mm]. Low high-density lipoprotein was prevalent in 67% and increased triglyceride in 28%. High triglyceride and low high-density lipoprotein levels were associated with low CD4 counts (P < 0.001). In this ART-naive Tanzanian population, dyslipidemia was highly prevalent and associated with advanced disease. The impact of ART on these changes requires further exploration.
摘要
在资源有限的环境下，有关感染 HIV 患者的血脂异常的数据十分有限。我们在 2004 年 11 月至 2008 年 6 月期间对坦桑尼亚未接受过抗逆转录病毒治疗（ART）、非空腹的 HIV 感染患者进行了一项横断面分析。我们进行了稳健线性回归建模。在 12513 名患者中评估了血脂参数[65%为女性；中位数（四分位距）年龄为 36（30-42）岁；CD4 计数为 143（51-290）个/立方毫米]。低高密度脂蛋白血症的患病率为 67%，高甘油三酯血症的患病率为 28%。高甘油三酯和低高密度脂蛋白水平与低 CD4 计数相关（P<0.001）。在这个未接受 ART 的坦桑尼亚人群中，血脂异常的患病率很高，且与疾病的晚期相关。ART 对这些变化的影响需要进一步探讨。
相似文献
1
Dyslipidemia in an HIV-positive antiretroviral treatment-naive population in Dar es Salaam, Tanzania.坦桑尼亚达累斯萨拉姆的 HIV 阳性、初治抗逆转录病毒治疗人群中的血脂异常。
J Acquir Immune Defic Syndr. 2011 Jun 1;57(2):141-5. doi: 10.1097/QAI.0b013e318219a3d1.
2
High prevalence of lipid abnormalities among antiretroviral-naive HIV-infected Asian children with mild-to-moderate immunosuppression.在未接受抗逆转录病毒治疗、轻度至中度免疫抑制的亚洲HIV感染儿童中，脂质异常的患病率很高。
Antivir Ther. 2011;16(8):1351-5. doi: 10.3851/IMP1897.
3
Prevalence of dyslipidaemia among HIV-infected patients receiving combination antiretroviral therapy in North Shewa, Ethiopia.埃塞俄比亚北谢瓦接受联合抗逆转录病毒治疗的艾滋病毒感染患者血脂异常的患病率。
PLoS One. 2021 Apr 27;16(4):e0250328. doi: 10.1371/journal.pone.0250328. eCollection 2021.
4
Dyslipidemia among HIV-infected Patients with tuberculosis taking once-daily nonnucleoside reverse-transcriptase inhibitor-based antiretroviral therapy in India.印度每日一次非核苷类逆转录酶抑制剂为基础的抗逆转录病毒治疗的结核感染艾滋病毒患者的血脂异常。
Clin Infect Dis. 2011 Feb 15;52(4):540-6. doi: 10.1093/cid/ciq195. Epub 2011 Jan 20.
5
Prevalence of Dyslipidemia Among Antiretroviral-Naive HIV-Infected Individuals in China.中国未接受抗逆转录病毒治疗的HIV感染者中血脂异常的患病率
Medicine (Baltimore). 2015 Dec;94(48):e2201. doi: 10.1097/MD.0000000000002201.
6
Anthropometric measurements and lipid profiles to detect early lipodystrophy in antiretroviral therapy experienced HIV-infected children in the CHAPAS-3 trial.在CHAPAS-3试验中，对接受抗逆转录病毒治疗的HIV感染儿童进行人体测量和血脂检测，以发现早期脂肪代谢障碍。
Antivir Ther. 2014;19(3):269-76. doi: 10.3851/IMP2695. Epub 2013 Oct 25.
7
Prevalence of hepatitis B co-infection and response to antiretroviral therapy among HIV-infected patients in Tanzania.坦桑尼亚感染 HIV 的患者中乙型肝炎合并感染的流行情况和对抗逆转录病毒治疗的反应。
AIDS. 2013 Mar 27;27(6):919-927. doi: 10.1097/QAD.0b013e32835cb9c8.
8
Contribution of genome-wide significant single-nucleotide polymorphisms and antiretroviral therapy to dyslipidemia in HIV-infected individuals: a longitudinal study.全基因组显著单核苷酸多态性和抗逆转录病毒疗法对HIV感染者血脂异常的影响：一项纵向研究
Circ Cardiovasc Genet. 2009 Dec;2(6):621-8. doi: 10.1161/CIRCGENETICS.109.874412. Epub 2009 Sep 18.
9
Dyslipidaemia in HIV-infected women on antiretroviral therapy. Analysis of 922 patients from the Spanish VACH cohort.抗反转录病毒治疗的 HIV 感染女性的血脂异常。来自西班牙 VACH 队列的 922 例患者分析。
BMC Womens Health. 2011 Aug 4;11:36. doi: 10.1186/1472-6874-11-36.
10
Magnitude of opportunistic infections and associated factors among HIV-infected individuals attending care and treatment clinics in Dar es Salaam, Tanzania: a hospital-based cross-sectional study.坦桑尼亚达累斯萨拉姆接受护理和治疗诊所治疗的艾滋病毒感染者中机会性感染的严重程度及相关因素：一项基于医院的横断面研究。
BMJ Open. 2025 Jan 20;15(1):e085725. doi: 10.1136/bmjopen-2024-085725.
引用本文的文献
1
Hypertension in HAART-naϊve HIV Subjects in Southeast Nigeria: A single-Center Study.尼日利亚东南部未接受高效抗逆转录病毒治疗的HIV感染者的高血压：一项单中心研究。
Niger Med J. 2023 Feb 24;63(5):425-431. eCollection 2022 Sep-Oct.
2
Lipids and apolipoproteins C-III and E among treatment-naïve and treatment-experienced persons with HIV in Nigeria.尼日利亚初治和经治HIV感染者的脂质、载脂蛋白C-III和载脂蛋白E
Afr J Lab Med. 2023 Jul 17;12(1):2018. doi: 10.4102/ajlm.v12i1.2018. eCollection 2023.
3
Prevalence and characteristics of metabolic syndrome and its components among adults living with and without HIV in Nigeria: a single-center study.在尼日利亚，患有和未患有 HIV 的成年人中代谢综合征及其成分的流行率和特征：一项单中心研究。
BMC Endocr Disord. 2023 Jul 28;23(1):160. doi: 10.1186/s12902-023-01419-x.
4
Metabolic Profile of People Living with HIV in a Treatment Hub in Manila, Philippines: A Pre- and Post-Antiretroviral Analysis.菲律宾马尼拉治疗中心的 HIV 感染者代谢特征：抗逆转录病毒治疗前后分析。
J ASEAN Fed Endocr Soc. 2022;37(1):53-61. doi: 10.15605/jafes.037.01.17. Epub 2022 Feb 18.
5
Dyslipidemia and associated risk factors among HIV/AIDS patients on HAART in Asmara, Eritrea.厄立特里亚阿斯马拉地区接受高效抗逆转录病毒治疗的艾滋病毒/艾滋病患者的血脂异常及相关危险因素。
PLoS One. 2022 Jul 1;17(7):e0270838. doi: 10.1371/journal.pone.0270838. eCollection 2022.
6
Serum Lipid Profiles of Patients Taking Efavirenz-Based Antiretroviral Regimen Compared to Ritonavir-Boosted Atazanavir with an Optimized Background at Zewditu Memorial Hospital, Addis Ababa, Ethiopia.在埃塞俄比亚亚的斯亚贝巴的泽维迪图纪念医院，对接受基于依非韦伦的抗逆转录病毒治疗方案的患者与在优化背景下使用利托那韦增强的阿扎那韦的患者的血脂谱进行比较。
HIV AIDS (Auckl). 2021 Feb 19;13:217-227. doi: 10.2147/HIV.S296170. eCollection 2021.
7
Evolution of blood lipids and risk factors of dyslipidemia among people living with human immunodeficiency virus who had received first-line antiretroviral regimens for 3 years in Shenzhen.深圳接受一线抗逆转录病毒治疗方案3年的人类免疫缺陷病毒感染者血脂变化及血脂异常危险因素
Chin Med J (Engl). 2020 Dec 5;133(23):2808-2815. doi: 10.1097/CM9.0000000000001245.
8
Cardiovascular risk factors among Ghanaian patients with HIV: A cross-sectional study.加纳 HIV 患者的心血管危险因素：一项横断面研究。
Clin Cardiol. 2019 Dec;42(12):1195-1201. doi: 10.1002/clc.23273. Epub 2019 Sep 30.
9
Models of integration of HIV and noncommunicable disease care in sub-Saharan Africa: lessons learned and evidence gaps.撒哈拉以南非洲地区将艾滋病病毒与非传染性疾病护理整合的模式：经验教训和证据空白。
AIDS. 2018 Jul 1;32 Suppl 1(Suppl 1):S33-S42. doi: 10.1097/QAD.0000000000001887.
10
Malnutrition and lipid abnormalities in antiretroviral naïve HIV-infected adults in Addis Ababa: A cross-sectional study.在亚的斯亚贝巴的抗逆转录病毒初治的 HIV 感染成年人中，营养不良和脂类异常：一项横断面研究。
PLoS One. 2018 Apr 19;13(4):e0195942. doi: 10.1371/journal.pone.0195942. eCollection 2018.
本文引用的文献
1
Association of immunologic and virologic factors with myocardial infarction rates in a US healthcare system.免疫和病毒因素与美国医疗体系中心肌梗死发生率的关系。
J Acquir Immune Defic Syndr. 2010 Dec 15;55(5):615-9. doi: 10.1097/QAI.0b013e3181f4b752.
2
Lipoprotein levels and cardiovascular risk in HIV-infected and uninfected Rwandan women.HIV 感染和未感染的卢旺达妇女的脂蛋白水平与心血管风险。
AIDS Res Ther. 2010 Aug 26;7:34. doi: 10.1186/1742-6405-7-34.
3
The comparison of alternative smoothing methods for fitting non-linear exposure-response relationships with Cox models in a simulation study.在一项模拟研究中，用Cox模型拟合非线性暴露-反应关系时替代平滑方法的比较。
Int J Biostat. 2009 Jan 7;5(1):Article 2. doi: 10.2202/1557-4679.1104.
4
Lipid abnormalities in a never-treated HIV-1 subtype C-infected African population.从未接受过治疗的HIV-1 C亚型感染非洲人群中的血脂异常
Lipids. 2010 Jan;45(1):73-80. doi: 10.1007/s11745-009-3369-4. Epub 2009 Nov 15.
5
Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and men.低CD4+ T细胞计数是HIV感染女性和男性动脉粥样硬化的主要危险因素。
AIDS. 2008 Aug 20;22(13):1615-24. doi: 10.1097/QAD.0b013e328300581d.
6
Prevalence of dyslipidemia and dysglycaemia in HIV infected patients.HIV感染患者中血脂异常和血糖异常的患病率。
East Afr Med J. 2008 Jan;85(1):10-7. doi: 10.4314/eamj.v85i1.9600.
7
Changes in lipid profile over 24 months among adults on first-line highly active antiretroviral therapy in the home-based AIDS care program in rural Uganda.乌干达农村家庭艾滋病护理项目中接受一线高效抗逆转录病毒治疗的成年人在24个月内的血脂变化情况。
J Acquir Immune Defic Syndr. 2008 Mar 1;47(3):304-11. doi: 10.1097/qai.0b013e31815e7453.
8
HIV infection and high density lipoprotein metabolism.HIV感染与高密度脂蛋白代谢
Atherosclerosis. 2008 Jul;199(1):79-86. doi: 10.1016/j.atherosclerosis.2007.10.018. Epub 2007 Dec 4.
9
Initiation of antiretroviral therapy at CD4 cell counts >/=350 cells/mm3 does not increase incidence or risk of peripheral neuropathy, anemia, or renal insufficiency.在CD4细胞计数≥350个细胞/立方毫米时开始抗逆转录病毒治疗不会增加周围神经病变、贫血或肾功能不全的发生率或风险。
J Acquir Immune Defic Syndr. 2008 Jan 1;47(1):27-35. doi: 10.1097/QAI.0b013e31815acacc.
10
Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease.感染人类免疫缺陷病毒疾病患者的急性心肌梗死发生率及心血管危险因素增加。
J Clin Endocrinol Metab. 2007 Jul;92(7):2506-12. doi: 10.1210/jc.2006-2190. Epub 2007 Apr 24.
Zotero 插件