Tabibzadeh S
Department of Pathology, City Hospital Center, Elmhurst, New York 11373.
J Clin Endocrinol Metab. 1990 Sep;71(3):645-9. doi: 10.1210/jcem-71-3-645.
Antigenic epitopes have been described whose expression characterizes early or late stages of activation of T-cells. In this study the expression of early activation antigen, interleukin-2 receptor was compared with the expression of late activation antigens, HLA-DR, HLA-DP, and HLA-DQ molecules of the major histocompatibility complex II, and very late activation antigen, VLA-1 of the integrin superfamily of molecules in 43 human endometria. These molecules were localized by their reactivity with monoclonal antibodies in an avidinbiotin-complex procedure. Interleukin-2 receptor was not expressed in human endometria; however, endometrial T-cells within lymphoid aggregates, some scattered in endometrial stroma and a few within epithelium, expressed HLA-DR, HLA-DP, HLA-DQ, and VLA-1. In addition, expression of the receptor of interferon-gamma, a product of activated T-cells, was observed on endometrial epithelium. Evidence for activation of T-cells and expression of interferon-gamma receptor in human endometrial epithelium suggests that endometrium may be an active site for cytokine action.
已经描述了一些抗原表位，其表达可表征T细胞激活的早期或晚期阶段。在本研究中，对43例人子宫内膜中早期激活抗原白细胞介素-2受体的表达与晚期激活抗原（主要组织相容性复合体II的HLA-DR、HLA-DP和HLA-DQ分子）以及整合素超家族分子中极晚期激活抗原VLA-1的表达进行了比较。这些分子通过在抗生物素蛋白-生物素复合物程序中与单克隆抗体的反应性进行定位。白细胞介素-2受体在人子宫内膜中不表达；然而，淋巴样聚集物中的子宫内膜T细胞、一些散在于子宫内膜基质中的T细胞以及少数上皮内的T细胞表达HLA-DR、HLA-DP、HLA-DQ和VLA-1。此外，在子宫内膜上皮上观察到激活的T细胞产物干扰素-γ受体的表达。人子宫内膜上皮中T细胞激活和干扰素-γ受体表达的证据表明，子宫内膜可能是细胞因子作用的活跃部位。
