Centre for Chronic Disease Control, New Delhi, India.
Nutr Metab (Lond). 2011 Mar 28;8(1):19. doi: 10.1186/1743-7075-8-19.
Inflammation, the key regulator of C-reactive protein (CRP) synthesis, plays a pivotal role in atherothrombotic cardiovascular disease.
High sensitivity CRP (hsCRP) analysis was carried out in randomly selected 600 individuals from the sentinel surveillance study in Indian industrial population (SSIP). The hsCRP was measured quantitatively by turbid metric test using kits from SPINREACT, Spain. We analyzed the association between hsCRP and traditional CVD risk factors in this sub-sample.
Complete risk factor data and CRP levels were available from 581/600 individuals. One half (51.2%) of the study subjects were males. Mean age of the study group was 39.2 ± 11.2 years. The Pearson correlation coefficients were in the range of 0.12 for SBP (p = 0.004) to 0.55 for BMI (p < 0.001). The linear regression coefficients ranged from 0.01 for SBP, PG and TC (p < 0.001) to 0.55 for logeTAG (p < 0.001) after adjustment for age, sex and education. The mean of logehsCRP significantly increased (P < 0.001) from individuals with ≤1 risk factors (-0.50) to individuals with three or more risk factors (0.60). In the multivariate model, the odds ratios for elevated CRP (CRP ≥ 2.6 mg/dl) were significantly elevated only in females in comparison to males (1.63, 95% CI; 1.02-2.58), overweight individuals in comparison to normal weight individuals (3.90, 95% CI; 2.34-6.44, p < 0.001), and abdominal obese individuals (1.62, 95% CI; 1.02-2.60, p = 0.04) in comparison to non-obese individuals.
Clinical measurements of adiposity (body mass index and abdominal obesity) correlate well and can be surrogate for systemic inflammatory state of individuals.
炎症是 C 反应蛋白（CRP）合成的关键调节因子，在动脉粥样硬化血栓形成性心血管疾病中起着关键作用。
在印度工业人群监测研究（SSIP）中随机选择 600 名个体进行高敏 CRP（hsCRP）分析。hsCRP 通过西班牙 SPINREACT 的试剂盒进行比浊法定量检测。我们在这个子样本中分析了 hsCRP 与传统 CVD 危险因素之间的关系。
581/600 名个体的完整危险因素数据和 CRP 水平可用。研究对象的一半（51.2%）为男性。研究组的平均年龄为 39.2±11.2 岁。Pearson 相关系数在 SBP 范围内为 0.12（p=0.004）至 BMI 范围为 0.55（p<0.001）。线性回归系数范围为 SBP、PG 和 TC 为 0.01（p<0.001）至 logeTAG 为 0.55（p<0.001），经年龄、性别和教育调整后。hsCRP 的平均值显著升高（P<0.001），从≤1 个危险因素的个体（-0.50）增加到 3 个或更多危险因素的个体（0.60）。在多元模型中，与男性相比，CRP（CRP≥2.6mg/dl）升高的比值比仅在女性中显著升高（1.63，95%置信区间；1.02-2.58），超重个体与正常体重个体（3.90，95%置信区间；2.34-6.44，p<0.001）相比，腹部肥胖个体（1.62，95%置信区间；1.02-2.60，p=0.04）与非肥胖个体相比。
临床测量的肥胖程度（体重指数和腹部肥胖）相关性良好，可作为个体全身炎症状态的替代指标。
