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在波多黎各进行的基于 PCR 的医院感染监测研究中，检测了产碳青霉烯酶肠杆菌科细菌（包括大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌）中的 KPC 基因。

Detection of the KPC gene in Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii during a PCR-based nosocomial surveillance study in Puerto Rico.

机构信息

Department of Microbiology and Medical Zoology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico.

出版信息

Antimicrob Agents Chemother. 2011 Jun;55(6):2968-70. doi: 10.1128/AAC.01633-10. Epub 2011 Mar 28.

DOI:10.1128/AAC.01633-10
PMID:21444702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3101463/
Abstract

A 6-month, PCR-based, island-wide hospital surveillance study of beta-lactam resistance in Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii was conducted in Puerto Rico. Of 10,507 isolates, 1,239 (12%) unique, multi-beta-lactam-resistant isolates from all geographical regions were identified. The KPC gene was detected in 61 E. coli, 333 K. pneumoniae, 99 P. aeruginosa, and 41 A. baumannii isolates, indicating the widespread dissemination of the KPC gene in clinically significant nosocomial isolates.

摘要

在波多黎各进行了一项为期 6 个月的基于 PCR 的全岛医院监测研究，以检测大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌的β-内酰胺耐药性。在 10507 株分离株中，从所有地理区域鉴定出 1239 株（12%）独特的多β-内酰胺耐药分离株。在 61 株大肠埃希菌、333 株肺炎克雷伯菌、99 株铜绿假单胞菌和 41 株鲍曼不动杆菌分离株中检测到 KPC 基因，表明 KPC 基因在临床上重要的医院分离株中广泛传播。

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本文引用的文献

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Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae.耐多药肠杆菌科中令人震惊的β-内酰胺酶介导的耐药性。
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Antimicrob Agents Chemother. 2010 Mar;54(3):1354-7. doi: 10.1128/AAC.00899-09. Epub 2009 Dec 28.
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