University of Puerto Rico, School of Medicine, Department of Microbiology and Medical Zoology, San Juan, Puerto Rico.
Antimicrob Agents Chemother. 2010 Mar;54(3):1354-7. doi: 10.1128/AAC.00899-09. Epub 2009 Dec 28.
During an island-wide PCR-based surveillance study of beta-lactam resistance in multidrug-resistant (MDR) Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter calcoaceticus-baumannii complex isolates obtained from 17 different hospitals, 10 KPC-positive Acinetobacter isolates were identified. DNA sequencing of the bla(KPC) gene identified KPC-2, -3, and -4 and a novel variant, KPC-10. This is the first report of a KPC-type beta-lactamase identified in Acinetobacter species.
在一项针对多药耐药(MDR)大肠杆菌、肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌分离株β-内酰胺耐药性的全岛基于 PCR 的监测研究中,从 17 家不同医院获得的 10 株产 KPC 阳性的鲍曼不动杆菌分离株被鉴定为阳性。bla(KPC)基因的 DNA 测序鉴定出 KPC-2、-3、-4 和一种新型变体 KPC-10。这是首次在鲍曼不动杆菌中发现 KPC 型β-内酰胺酶。