Brain Imaging and Analysis Center, Duke University, Durham, North Carolina 27708, USA.
J Neurosci. 2011 Mar 30;31(13):5026-31. doi: 10.1523/JNEUROSCI.5762-10.2011.
The dorsomedial and dorsolateral prefrontal cortices (dmPFC and dlPFC) together support cognitive control, with dmPFC responsible for monitoring performance and dlPFC responsible for adjusting behavior. The dlPFC contains a topographic organization that reflects complexity of control demands, with more anterior regions guiding increasingly abstract processing. Recent evidence for a similar gradient within dmPFC suggests the possibility of parallel, hierarchical organization. Here, we measured connectivity between functional nodes of dmPFC and dlPFC using resting-state functional magnetic resonance imaging in humans. We found a posterior-to-anterior connectivity gradient; posterior dmPFC maximally connected to posterior dlPFC and anterior dmPFC maximally connected to anterior dlPFC. This parallel topographic pattern replicated across three independent datasets collected on different scanners, within individual participants, and through both point-to-point and voxelwise analyses. We posit a model of cognitive control characterized by hierarchical interactions--whose level depends on current environmental demands--between functional subdivisions of medial and lateral PFC.
背内侧前额叶皮层和背外侧前额叶皮层（dmPFC 和 dlPFC）共同支持认知控制，其中 dmPFC 负责监控表现，dlPFC 负责调整行为。dlPFC 包含一个反映控制需求复杂性的拓扑组织，其中更靠前的区域指导越来越抽象的处理。最近在 dmPFC 中发现了类似的梯度证据，表明存在平行的层次组织的可能性。在这里，我们使用静息态功能磁共振成像在人类中测量了 dmPFC 和 dlPFC 之间的功能节点之间的连通性。我们发现了一个从后到前的连接梯度；后 dmPFC 与后 dlPFC 最大连接，前 dmPFC 与前 dlPFC 最大连接。这种平行的拓扑模式在三个独立的数据集上得到了复制，这些数据集是在不同的扫描仪上、在个体参与者内、通过点对点和体素分析收集的。我们提出了一个认知控制模型，其特征是内侧和外侧前额叶皮层的功能细分之间存在层次交互--其水平取决于当前的环境需求。
