Chakraborty Manodeep, Asdaq Syed Mohammed Basheeruddin
Department of Pharmacology, Krupanidhi College of Pharmacy, Varthur Hobli, Chikkabellandur Village, Carmalaram Post, Bangalore 560 035, India.
Indian J Exp Biol. 2011 Mar;49(3):200-6.
With a view to evaluate the cardioprotective effect of ethanolic extract of S. anacardium nut and the possible interaction with propranolol against isoproterenol induced myocardial damage in rats, female Sprague-Dawley rats were pre-treated with propranolol (10 mg/kg for 7 days), low and high doses of S. anacardium (100 and 500 mg/kg for 21 days) and their combination orally and subsequently subjected to isoproterenol administration (150 mg/kg, sc) for two consecutive days. The influence of prophylactic treatment was analysed by quantification of biomarkers and antioxidants, electocardiographic parameters and histopathological observations. The activities of lactate dehydrogenase and creatinine phosphokinase-MB were reduced in serum and raised in heart tissue with concurrent elevation in superoxide dismutase and catalase activities as well as reduction in thiobarbituric acid reactive species levels significantly in all treated groups compared to isoproterenol group. Similarly, electrocardiographic changes were restored to normalcy in all treated groups. To conclude, combination of high dose of S. anacardium with propranolol was found to be most effective in alleviating the abnormal conditions induced by isoproterenol.
为了评估腰果坚果乙醇提取物的心脏保护作用以及其与普萘洛尔联合使用对异丙肾上腺素诱导的大鼠心肌损伤的可能相互作用，将雌性斯普拉格 - 道利大鼠口服给予普萘洛尔（10 mg/kg，连续7天）、低剂量和高剂量的腰果（100和500 mg/kg，连续21天）及其组合进行预处理，随后连续两天皮下注射异丙肾上腺素（150 mg/kg）。通过对生物标志物和抗氧化剂进行定量、心电图参数分析以及组织病理学观察来分析预防性治疗的影响。与异丙肾上腺素组相比，所有治疗组血清中乳酸脱氢酶和肌酸磷酸激酶 - MB的活性降低，心脏组织中升高，同时超氧化物歧化酶和过氧化氢酶活性升高，硫代巴比妥酸反应性物质水平降低。同样，所有治疗组的心电图变化均恢复正常。总之，发现高剂量的腰果与普萘洛尔联合使用在减轻异丙肾上腺素诱导的异常情况方面最有效。
