Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Parkinsonism Relat Disord. 2011 Jul;17(6):446-50. doi: 10.1016/j.parkreldis.2011.02.016. Epub 2011 Apr 1.
Studies that have addressed the association between the intake of coffee or caffeine and Parkinson's disease (PD) were conducted mainly in Western countries. Little is known about this relationship in an Asian population. Therefore, we performed an assessment of the association of the intake of coffee, other caffeine-containing beverages, and caffeine with the risk of PD in Japan. The study involved 249 PD cases and 368 control subjects. Information on dietary factors was obtained through a self-administered diet history questionnaire. Adjustment was made for sex, age, region of residence, educational level, pack-years of smoking, body mass index, the dietary glycemic index, and intake of cholesterol, vitamin E, β-carotene, vitamin B(6,) alcohol, and iron. Intake of coffee, black tea, and Japanese and Chinese teas was significantly inversely associated with the risk of PD: the adjusted odds ratios in comparison of the highest with the lowest quartile were 0.52, 0.58, and 0.59, respectively (95% confidence intervals = 0.30-0.90, 0.35-0.97, and 0.35-0.995, respectively). A clear inverse dose-response relationship between total caffeine intake and PD risk was observed. We confirmed that the intake of coffee and caffeine reduced the risk of PD. Furthermore, this is the first study to show a significant inverse relationship between the intake of Japanese and Chinese teas and the risk of PD.
在西方各国进行的研究主要探讨了咖啡或咖啡因的摄入与帕金森病（PD）之间的关系。在亚洲人群中，对这种关系知之甚少。因此，我们评估了在日本咖啡、其他含咖啡因饮料和咖啡因的摄入与 PD 风险之间的关系。该研究纳入了 249 例 PD 病例和 368 例对照。通过自我管理的饮食史问卷获取有关饮食因素的信息。调整了性别、年龄、居住地区、教育程度、吸烟包年数、体重指数、饮食血糖指数以及胆固醇、维生素 E、β-胡萝卜素、维生素 B(6)、酒精和铁的摄入量。咖啡、红茶、日本茶和中国茶的摄入量与 PD 风险呈显著负相关：最高四分位组与最低四分位组相比，调整后的比值比分别为 0.52、0.58 和 0.59（95%置信区间=0.30-0.90、0.35-0.97 和 0.35-0.995）。总咖啡因摄入量与 PD 风险之间存在明显的负剂量反应关系。我们证实咖啡和咖啡因的摄入降低了 PD 的风险。此外，这是第一项表明日本茶和中国茶摄入量与 PD 风险呈显著负相关的研究。
