Scriba M
Med Microbiol Immunol. 1978 Nov 17;166(1-4):63-9. doi: 10.1007/BF02121135.
Guinea pigs, inoculated intravaginally with HSV type 2 develop a primary and spontaneously recurring genital herpes with clinical symptoms resembling genital herpes in humans. The effect of a previous infection with either HSV type 1 or HSV type 2 on the clinical course of the intravaginal challenge infection was studied. Prior infection with either subtype of HSV moderated considerably the acute disease induced by intravaginal HSV type 2 challenge. No effect was, however, observed on the development of the chronic phase of the challenge infection. The significance of these studies for the possibility of vaccination against recurrent herpes infections is discussed.
将2型单纯疱疹病毒经阴道接种豚鼠后，会引发原发性且自然复发的生殖器疱疹，其临床症状与人类生殖器疱疹相似。研究了先前感染1型单纯疱疹病毒或2型单纯疱疹病毒对经阴道激发感染临床病程的影响。先前感染任何一种单纯疱疹病毒亚型均可显著减轻经阴道接种2型单纯疱疹病毒激发所诱发的急性疾病。然而，未观察到对激发感染慢性期发展的影响。讨论了这些研究对于预防复发性疱疹感染疫苗接种可能性的意义。
