The Royal Swedish Academy of Sciences, The Sven Lovén Centre for Marine Sciences, Kristineberg 566, 450 34 Fiskebäckskil, Sweden.
Aquat Toxicol. 2011 Jun;103(3-4):222-4. doi: 10.1016/j.aquatox.2011.03.001. Epub 2011 Mar 5.
We compared effects of exposure to predict near-future (2100) ocean acidification (OA; pH 7.7) and normal seawater (Control; pH 8.1) on immune and stress responses in the adult sea star Asterias rubens. Analyses were made after one week and after six months of continuous exposure. Following one week exposure to acidified water, the pH of coelomic fluid was significantly reduced. Levels of the chaperon Hsp70 were elevated while key cellular players in immunity, coelomocytes, were reduced by approximately 50%. Following long-term exposure (six months) levels of Hsp70 returned to control values, whereas immunity was further impaired, evidenced by the reduced phagocytic capacity of coelomocytes and inhibited activation of p38 MAP-kinase. Such impacts of reduced seawater pH may have serious consequences for resistance to pathogens in a future acidified ocean.
我们比较了暴露于预测的近未来（2100 年）海洋酸化（OA；pH7.7）和正常海水（对照；pH8.1）对成年海星 Asterias rubens 的免疫和应激反应的影响。在连续暴露一周和六个月后进行了分析。酸化水暴露一周后，体腔液的 pH 值显著降低。伴侣蛋白 Hsp70 的水平升高，而免疫的关键细胞因子——体腔细胞减少了约 50%。长期暴露（六个月）后，Hsp70 的水平恢复到对照值，而免疫功能进一步受损，体腔细胞的吞噬能力降低，p38MAP-激酶的激活受到抑制。海水 pH 值降低可能对未来酸化海洋中病原体的抵抗力产生严重影响。
